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Adjunctive mood stabilizer treatment for hospitalized schizophrenia patients: Asia psychotropic prescription study (2001-2008)
Sim K.13; Yong K.H.13; Chan Y.H.8; Tor P.-C.15; Xiang Y.-T.3; Wang C.-Y.3; Lee E.H.M.10; Fujii S.1; Yang S.-Y.5; Chong M.-Y.9; Ungvari G.S.7; Si T.12; He Y.L.16; Chung E.K.6; Chee K.Y.2; Trivedi J.11; Udomratn P.18; Shinfuku N.17; Kua E.H.15; Tan C.H.15; Sartorius N.14; Baldessarini R.J.4
2011-10-01
Source PublicationInternational Journal of Neuropsychopharmacology
ISSN14611457 14695111
Volume14Issue:9Pages:1157-1164
AbstractRecent studies indicate relatively high international rates of adjunctive psychotropic medication, including mood stabilizers, for patients with schizophrenia. Since such treatments are little studied in Asia, we examined the frequency of mood-stabilizer use and its clinical correlates among hospitalized Asian patients diagnosed with schizophrenia in 2001-2008. We evaluated usage rates of mood stabilizers with antipsychotic drugs, and associated factors, for in-patients diagnosed with DSM-IV schizophrenia in 2001, 2004 and 2008 in nine Asian regions: China, Hong Kong, India, Korea, Japan, Malaysia, Taiwan, Thailand, and Singapore. Overall, mood stabilizers were given to 20.4% (n=1377/6761) of hospitalized schizophrenia patients, with increased usage over time. Mood-stabilizer use was significantly and independently associated in multivariate logistic modeling with: aggressive behaviour, disorganized speech, year sampled (2008 vs. earlier), multiple hospitalizations, less negative symptoms, younger age, with regional variation (Japan, Hong Kong, Singapore>Taiwan or China). Co-prescription of adjunctive mood stabilizers with antipsychotics for hospitalized Asian schizophrenia patients increased over the past decade, and was associated with specific clinical characteristics. This practice parallels findings in other countries and illustrates ongoing tension between evidence-based practice vs. individualized, empirical treatment of psychotic disorders. © 2011 CINP.
KeywordAdjunctive clinical mood stabilizers schizophrenia treatment
DOI10.1017/S1461145711000563
URLView the original
Language英語
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Cited Times [WOS]:20   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Hyogo Institute for Traumatic Stress
2.Kuala Lumpur Hospital
3.Beijing An Ding Hospital, Capital Medical University
4.McLean Hospital
5.Taipei City Hospital Taiwan
6.Seoul National University
7.University of Western Australia
8.National University of Singapore
9.Chang Gung University
10.Chinese University of Hong Kong
11.Chhatrapati Shahuji Maharaj Medical University
12.Peking University Health Science Center
13.Singapore Institute of Mental Health
14.Université de Genève
15.National University Hospital, Singapore
16.Shanghai Mental Health Center
17.Seinan Gakuin University
18.Prince of Songkla University
Recommended Citation
GB/T 7714
Sim K.,Yong K.H.,Chan Y.H.,et al. Adjunctive mood stabilizer treatment for hospitalized schizophrenia patients: Asia psychotropic prescription study (2001-2008)[J]. International Journal of Neuropsychopharmacology,2011,14(9):1157-1164.
APA Sim K..,Yong K.H..,Chan Y.H..,Tor P.-C..,Xiang Y.-T..,Wang C.-Y..,Lee E.H.M..,Fujii S..,Yang S.-Y..,Chong M.-Y..,Ungvari G.S..,Si T..,He Y.L..,Chung E.K..,Chee K.Y..,Trivedi J..,Udomratn P..,Shinfuku N..,Kua E.H..,...&Baldessarini R.J..(2011).Adjunctive mood stabilizer treatment for hospitalized schizophrenia patients: Asia psychotropic prescription study (2001-2008).International Journal of Neuropsychopharmacology,14(9),1157-1164.
MLA Sim K.,et al."Adjunctive mood stabilizer treatment for hospitalized schizophrenia patients: Asia psychotropic prescription study (2001-2008)".International Journal of Neuropsychopharmacology 14.9(2011):1157-1164.
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