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Polygonum multiflorum Thunb.: A Review on Chemical Analysis, Processing Mechanism, Quality Evaluation, and Hepatotoxicity
Liu, Yue; Wang, Qi; Yang, Jianbo; Guo, Xiaohan; Liu, Wenxi; Ma, Shuangcheng; Li, Shaoping
2018-04-16
Source PublicationFRONTIERS IN PHARMACOLOGY
ISSN1663-9812
Volume9
AbstractPolygonum multiflorum Thunb. and its processed products have been used in China for centuries due to their multiple beneficial effects to human body. Currently, liver injuries caused by taking P. multiflorum have been reported worldwide, but the potential toxic components and possible mechanism that caused hepatotoxicity remain unclear. It is worth noting that the processing procedure could significantly decrease the toxicity of raw P. multiflorum and the processed products of P. multiflorum are considered to be relatively safe. However, the processing mechanism is still ambiguous, and there is the lack of a scientific approach to control the quality of P. multiflorum praeparata. This study is the first review that summarizes the recently advances (from 2007 to 2017) in the chemical analysis of P. multiflorum, and provides comprehensive information on the quantitative and qualitative analysis of P. multiflorum as well as its related species. In addition, the processing mechanism and quality evaluation of processed P. multiflorum are discussed. Moreover, the toxicity of P. multiflorum is analyzed from the perspectives of exploration of the proposed toxic ingredients, metabolite identification, metabolomics studies, and exogenous contaminant determination. Furthermore, trends and perspectives for future research of this medicine are discussed.
KeywordPolygonum multiflorum thunb. chemical analysis processing mechanism quality evaluation hepatotoxicity stilbene glucosides anthraquinones review
DOI10.3389/fphar.2018.00364
URLView the original
Indexed BySCIE
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000430098400001
PublisherFRONTIERS MEDIA SA
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:30   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Liu, Yue,Wang, Qi,Yang, Jianbo,et al. Polygonum multiflorum Thunb.: A Review on Chemical Analysis, Processing Mechanism, Quality Evaluation, and Hepatotoxicity[J]. FRONTIERS IN PHARMACOLOGY,2018,9.
APA Liu, Yue,Wang, Qi,Yang, Jianbo,Guo, Xiaohan,Liu, Wenxi,Ma, Shuangcheng,&Li, Shaoping.(2018).Polygonum multiflorum Thunb.: A Review on Chemical Analysis, Processing Mechanism, Quality Evaluation, and Hepatotoxicity.FRONTIERS IN PHARMACOLOGY,9.
MLA Liu, Yue,et al."Polygonum multiflorum Thunb.: A Review on Chemical Analysis, Processing Mechanism, Quality Evaluation, and Hepatotoxicity".FRONTIERS IN PHARMACOLOGY 9(2018).
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