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A novel anti-cancer agent, acetyltanshinone IIA, inhibits oestrogen receptor positive breast cancer cell growth by down-regulating the oestrogen receptor
Yu T.1; Zhou Z.1; Mu Y.1; De Lima Lopes G.2; Luo K.Q.1
2014-04-28
Source PublicationCancer Letters
ISSN18727980 03043835
Volume346Issue:1Pages:94-103
Abstract

In this paper we show that acetyltanshinone IIA (ATA), a novel anti-cancer agent, preferentially inhibits cell growth of oestrogen receptor positive (ER+) breast cancer cells and that it is more potent than the commonly used anti-breast cancer agent, tamoxifen. The metabolic product of ATA, hydroquinone tanshinone IIA (HTA) binds to the ERα and causes its degradation mainly in the nucleus via an ubiquitin-mediated proteasome-dependent pathway. In addition, ATA also reduced the mRNA levels of the ERα encoding gene, ESR1, distinguishing ATA from another anti-breast cancer drug, fulvestrant. Finally, ATA reduced the transcription of an ER-responsive gene, GREB1. © 2013 Elsevier Ireland Ltd.

KeywordAcetyltanshinone Iia Anti-breast Cancer Agent Fulvestrant Oestrogen Receptor Tamoxifen
DOI10.1016/j.canlet.2013.12.023
URLView the original
Indexed BySCI
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000334017000011
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Citation statistics
Cited Times [WOS]:24   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Nanyang Technological University
2.Johns Hopkins Singapore
Recommended Citation
GB/T 7714
Yu T.,Zhou Z.,Mu Y.,et al. A novel anti-cancer agent, acetyltanshinone IIA, inhibits oestrogen receptor positive breast cancer cell growth by down-regulating the oestrogen receptor[J]. Cancer Letters,2014,346(1):94-103.
APA Yu T.,Zhou Z.,Mu Y.,De Lima Lopes G.,&Luo K.Q..(2014).A novel anti-cancer agent, acetyltanshinone IIA, inhibits oestrogen receptor positive breast cancer cell growth by down-regulating the oestrogen receptor.Cancer Letters,346(1),94-103.
MLA Yu T.,et al."A novel anti-cancer agent, acetyltanshinone IIA, inhibits oestrogen receptor positive breast cancer cell growth by down-regulating the oestrogen receptor".Cancer Letters 346.1(2014):94-103.
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