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Monolithic Multiband CMUTs for Photoacoustic Computed Tomography with In Vivo Biological Tissue Imaging
Pun, Sio Hang1; Yu, Yuanyu1,2; Zhang, Jian1,3; Wang, Jiujiang1; Cheng, Ching-Hsiang3,4; Lei, Kin Fong6,7; Yuan, Zhen1; Mak, Peng Un1
2018-03
Source PublicationIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
ISSN0885-3010
Volume65Issue:3Pages:465-475
Abstract

Among the biomedical imaging modalities, photoacoustic computed tomography (PACT) was one of the emerging hybrid techniques in recent years. In designing the PACT imaging system, a finite-bandwidth transducer is one of the limited factors for the overall performance. As the target size is inversely proportional to the dominant frequency components of the generated photoacoustic (PA) signal, a broad bandwidth transducer is desired for different scales' imaging. In this paper, a monolithic multiband capacitive micromachined ultrasonic transducer (CMUT) array was designed and fabricated for the reception of the wideband PA signals so as to provide high-resolution images with high-frequency CMUT arrays and present the high signal-to-noise-ratio major structure with low-frequency CMUT arrays. To demonstrate its performance, a phantom experiment was conducted to show and evaluate the various qualities of multiresolution images. In addition, an in vivo mouse model experiment was also carried out for revealing the multiscale PA imaging capability with the multiband CMUTs on biological tissues. From the obtained results, the images from different CMUT arrays could show the structures of the mouse brain in different scales. In addition, the images from the high-frequency CMUT arrays were able to reveal the major blood vasculatures, whereas the images from low-frequency CMUT arrays showed the gross macroscopic anatomy of the brain with higher contrast.

KeywordCapacitive Micromachined Ultrasonic Transducer (Cmut) Multiband Cmut Photoacoustic Computed Tomography (Pact)
DOI10.1109/TUFFC.2018.2792784
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaAcoustics
WOS SubjectEngineering
WOS IDWOS:000426691300016
PublisherIEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
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Cited Times [WOS]:18   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionINSTITUTE OF MICROELECTRONICS
Affiliation1.University of Macau
2.Lingnan Normal University
3.Guangzhou Med University
4.Hong Kong Polytech University
5.Wuhan University Technol
6.Chang Gung University, Grad Inst Med Mechatron, Taoyuan 33302, Taiwan
7.Chang Gung Mem Hosp, Dept Radiat Oncol, Taoyuan 33305, Taiwan
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Pun, Sio Hang,Yu, Yuanyu,Zhang, Jian,et al. Monolithic Multiband CMUTs for Photoacoustic Computed Tomography with In Vivo Biological Tissue Imaging[J]. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control,2018,65(3):465-475.
APA Pun, Sio Hang,Yu, Yuanyu,Zhang, Jian,Wang, Jiujiang,Cheng, Ching-Hsiang,Lei, Kin Fong,Yuan, Zhen,&Mak, Peng Un.(2018).Monolithic Multiband CMUTs for Photoacoustic Computed Tomography with In Vivo Biological Tissue Imaging.IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control,65(3),465-475.
MLA Pun, Sio Hang,et al."Monolithic Multiband CMUTs for Photoacoustic Computed Tomography with In Vivo Biological Tissue Imaging".IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 65.3(2018):465-475.
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