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Multiscale and Multifunctional Emulsions by Host-Guest Interaction-Mediated Self-Assembly
Han, Songling1; Chen, Siyu1,2; Li, Lanlan1,3; Li, Jin1; An, Huijie1; Tao, Hui1; Jia, Yi1; Lu, Shan1; Wang, Ruibing3; Zhang, Jianxiang1

Emulsions are widely used in numerous fields. Therefore, there has been increasing interest in the development of new emulsification strategies toward emulsions with advanced functions. Herein we report the formation of diverse emulsions by host-guest interaction-mediated interfacial self-assembly under mild conditions. In this strategy, a hydrophilic diblock copolymer with one block containing beta-cyclodextrin (beta-CD) can assemble at the oil/water interface when its aqueous solution is mixed with an oil phase of benzyl alcohol (BA), by host-guest interactions between beta-CD and BA. This results in significantly reduced interfacial tension and the formation of switchable emulsions with easily tunable droplet sizes. Furthermore, nanoemulsions with excellent stability are successfully prepared simply via vortexing. The self-assembled oil-in-water emulsions also show catastrophic phase inversion, which can generate stable bicontinuous phase and water-in-oil emulsions, thereby further extending phase structures that can be realized by this host-guest self-assembly approach. Moreover, the host-guest nanoemulsions are able to engineer different nanoparticles and microstructures as well as solubilize a diverse array of hydrophobic drugs and dramatically enhance their oral bioavailability. The host-guest self-assembly emulsification is facile, energetically friendly, and fully translatable to industry, therefore representing a conceptually creative approach toward advanced emulsions.

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Indexed BySCIE
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000434851700013
The Source to ArticleWOS
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Cited Times [WOS]:15   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorWang, Ruibing; Zhang, Jianxiang
Affiliation1.Department of Pharmaceutics, College of Pharmacy, Third Military Medical University, Chongqing 400038, China
2.Experimental Teaching Management Center, Bin Zhou Medical University, Yantai 264000, China
3.State Key Laboratory of Quality Research in Chinese Medicine, and Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau, China
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Han, Songling,Chen, Siyu,Li, Lanlan,et al. Multiscale and Multifunctional Emulsions by Host-Guest Interaction-Mediated Self-Assembly[J]. ACS CENTRAL SCIENCE,2018,4(5):600-605.
APA Han, Songling,Chen, Siyu,Li, Lanlan,Li, Jin,An, Huijie,Tao, Hui,Jia, Yi,Lu, Shan,Wang, Ruibing,&Zhang, Jianxiang.(2018).Multiscale and Multifunctional Emulsions by Host-Guest Interaction-Mediated Self-Assembly.ACS CENTRAL SCIENCE,4(5),600-605.
MLA Han, Songling,et al."Multiscale and Multifunctional Emulsions by Host-Guest Interaction-Mediated Self-Assembly".ACS CENTRAL SCIENCE 4.5(2018):600-605.
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