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Epigenetic modulation by inorganic metal complexes
Leung CH1; Liu LJ1; Leung KH2; Ma DL2
2016
Source PublicationCoord Chem Rev
ISSN0010-8545
Volume319Pages:25-34
Abstract

Epigenetic mechanisms have emerged as key targets for therapeutic intervention. However, while a number of organic small-molecular “epidrugs” have been approved for clinical use, no metal-based epigenetic modulator have been successfully approved. Metal complexes exhibit a variety of distinct properties that make them viable alternatives to organic molecules as therapeutic agents. In this review, we highlight recent examples of epigenetic modulation by metal complexes, with a view towards showcasing the different mechanisms exploited by metal complexes for targeting either epigenetic marks or epigenetic pathways for potential therapeutic applications.

KeywordTransition Metal Complexes Epidrugs Histone Chromatin-modifying Enzymes Epigenetic
DOIhttps://doi.org/10.1016/j.ccr.2016.03.014
Indexed BySCIE
Language英語English
WOS Research AreaChemistry
WOS SubjectChemistry, Inorganic & Nuclear
WOS IDWOS:000378455300002
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Cited Times [WOS]:11   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
2.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Leung CH,Liu LJ,Leung KH,et al. Epigenetic modulation by inorganic metal complexes[J]. Coord Chem Rev,2016,319:25-34.
APA Leung CH,Liu LJ,Leung KH,&Ma DL.(2016).Epigenetic modulation by inorganic metal complexes.Coord Chem Rev,319,25-34.
MLA Leung CH,et al."Epigenetic modulation by inorganic metal complexes".Coord Chem Rev 319(2016):25-34.
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