UM  > Institute of Chinese Medical Sciences
Potential Antineoplastic Effects of Aloe-emodin: A Comprehensive Review
Chen RE; Zhang JM; Hu YY; Wang SP; Chen MW; Wang YT
Source PublicationAmerican Journal of Chinese Medicine

Aloe-emodin (AE), a bioactive anthraquinone derived from both Aloe vera and Rheum officinale, has recently been demonstrated to have various pharmacological activities. With the widespread popularity of natural products, such as antineoplastic drugs, AE has attracted much attention due to its remarkable antineoplastic activity on multiple tumor cells involving multi-channel mechanisms, including the disruption of cell cycle, induction of apoptosis, anti-metastasis, antiangiogenic, and strengthening of immune function. Experimental data have revealed AE as a potentially potent anti-cancer candidate. Despite this, the pharmaceutical application of AE is still in a fledging period as most research has concentrated on the elucidation of the molecular mechanism of action of existing treatments, rather than the development of novel formulations. Therefore, the present review summarizes the potential toxicity, molecular mechanism, pharmacokinetic characteristics, and pharmaceutical development of AE as an antineoplastic agent. This is based on its physicochemical properties, in an attempt to encourage further research on AE as a potential anti-cancer agent.

KeywordAloe-emodin Chemotherapy Toxicity Anti-cancer Activity Review
Indexed BySCI
WOS Research AreaIntegrative & Complementary Medicine ; General & Internal Medicine
WOS SubjectIntegrative & Complementary Medicine ; Medicine, General & Internal
WOS IDWOS:000333091500002
Fulltext Access
Citation statistics
Cited Times [WOS]:49   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationState Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences, University of Macau Macau SAR, 999078, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Chen RE,Zhang JM,Hu YY,et al. Potential Antineoplastic Effects of Aloe-emodin: A Comprehensive Review[J]. American Journal of Chinese Medicine,2014,42(2):275–288.
APA Chen RE,Zhang JM,Hu YY,Wang SP,Chen MW,&Wang YT.(2014).Potential Antineoplastic Effects of Aloe-emodin: A Comprehensive Review.American Journal of Chinese Medicine,42(2),275–288.
MLA Chen RE,et al."Potential Antineoplastic Effects of Aloe-emodin: A Comprehensive Review".American Journal of Chinese Medicine 42.2(2014):275–288.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Chen RE]'s Articles
[Zhang JM]'s Articles
[Hu YY]'s Articles
Baidu academic
Similar articles in Baidu academic
[Chen RE]'s Articles
[Zhang JM]'s Articles
[Hu YY]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Chen RE]'s Articles
[Zhang JM]'s Articles
[Hu YY]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.