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Saponins from Chinese Medicines as Anticancer Agents
Xu XH1; Li T1; Fong CMV1; Chen XP1; Chen XJ1; Wang YT1; Huang MQ2; Lu JJ1
Source PublicationMolecules

Saponins are glycosides with triterpenoid or spirostane aglycones that demonstrate various pharmacological effects against mammalian diseases. To promote the research and development of anticancer agents from saponins, this review focuses on the anticancer properties of several typical naturally derived triterpenoid saponins (ginsenosides and saikosaponins) and steroid saponins (dioscin, polyphyllin, and timosaponin) isolated from Chinese medicines. These saponins exhibit in vitro and in vivo anticancer effects, such as anti-proliferation, anti-metastasis, anti-angiogenesis, anti-multidrug resistance, and autophagy regulation actions. In addition, related signaling pathways and target proteins involved in the anticancer effects of saponins are also summarized in this work.

KeywordTriterpenoid Saponins Steroid Saponins Mechanism Target Cancer
Indexed BySCIE
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000389917900063
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Cited Times [WOS]:48   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
2.College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Xu XH,Li T,Fong CMV,et al. Saponins from Chinese Medicines as Anticancer Agents[J]. Molecules,2016,21(10):1326.
APA Xu XH,Li T,Fong CMV,Chen XP,Chen XJ,Wang YT,Huang MQ,&Lu JJ.(2016).Saponins from Chinese Medicines as Anticancer Agents.Molecules,21(10),1326.
MLA Xu XH,et al."Saponins from Chinese Medicines as Anticancer Agents".Molecules 21.10(2016):1326.
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