Suppression of LPS-induced tau hyperphosphorylation by serum amyloid A
Liu J.1; Wang D.1; Li S.-Q.1; Yu Y.1; Ye R.D.1
Source PublicationJournal of Neuroinflammation
AbstractBackground: Accumulation of hyperphosphorylated tau is a major neuropathological feature of tauopathies including Alzheimer's disease (AD). Serum amyloid A (SAA), an acute-phase protein with cytokine-like property, has been implicated in amyloid deposition. It remains unclear whether SAA affects tau hyperphosphorylation. Methods: Potential involvement of SAA in tau hyperphosphorylation was examined using intracerebral injection of SAA, and in Saa3 mice receiving systemic administration of lipopolysaccharide (LPS). Induced SAA expression and microglial activation were evaluated in these mice using real-time PCR and/or immunofluorescence staining. Cultured primary neuronal cells were treated with condition media (CM) from SAA-stimulated primary microglial cells. The alteration in tau hyperphosphorylation was determined using Western blotting. Results: Saa3 is the predominant form of SAA proteins induced by LPS in the mouse brain that co-localizes with neurons. Overexpression of SAA by intracerebral injection attenuated tau hyperphosphorylation in the brain. Conversely, Saa3 deficiency enhanced tau phosphorylation induced by systemic LPS administration. Intracerebral injection of SAA also induced the activation of microglia in the brains. IL-10 released to CM from SAA-stimulated microglia attenuated tau hyperphosphorylation in cultured primary neurons. IL-10 neutralizing antibody reversed the effect of SAA in the attenuation of tau phosphorylation. Conclusions: LPS-induced expression of SAA proteins in the brain leads to the activation of microglia and release of IL-10, which in turn suppresses tau hyperphosphorylation in a mouse model of systemic inflammation.
KeywordAlzheimer's disease Microglial activation Serum amyloid A Tau phosphorylation
URLView the original
Fulltext Access
Citation statistics
Cited Times [WOS]:23   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Shanghai Jiao Tong University
2.University of Macau
Recommended Citation
GB/T 7714
Liu J.,Wang D.,Li S.-Q.,et al. Suppression of LPS-induced tau hyperphosphorylation by serum amyloid A[J]. Journal of Neuroinflammation,2016,13(1).
APA Liu J.,Wang D.,Li S.-Q.,Yu Y.,&Ye R.D..(2016).Suppression of LPS-induced tau hyperphosphorylation by serum amyloid A.Journal of Neuroinflammation,13(1).
MLA Liu J.,et al."Suppression of LPS-induced tau hyperphosphorylation by serum amyloid A".Journal of Neuroinflammation 13.1(2016).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Liu J.]'s Articles
[Wang D.]'s Articles
[Li S.-Q.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Liu J.]'s Articles
[Wang D.]'s Articles
[Li S.-Q.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Liu J.]'s Articles
[Wang D.]'s Articles
[Li S.-Q.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.