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A rhodium(III) complex inhibits LPS-induced nitric oxide production and angiogenic activity in cellulo
Liu L.-J.3; Lin S.1; Chan D.S.-H.1; Vong C.T.3; Hoi P.M.3; Wong C.-Y.2; Ma D.-L.1; Leung C.-H.3
2014
Source PublicationJournal of Inorganic Biochemistry
ISSN18733344 01620134
Volume140Pages:23-28
Abstract

Metal-containing complexes have arisen as viable alternatives to organic molecules as therapeutic agents. Metal complexes possess a number of advantages compared to conventional carbon-based compounds, such as distinct geometries, interesting electronic properties, variable oxidation states and the ability to arrange different ligands around the metal centre in a precise fashion. Meanwhile, nitric oxide (NO) plays key roles in the regulation of angiogenesis, vascular permeability and inflammation. We herein report a novel cyclometalated rhodium(III) complex as an inhibitor of lipopolysaccharides (LPS)-induced NO production in RAW264.7 macrophages. Experiments suggested that the inhibition of NO production in cells by complex 1 was mediated through the down-regulation of nuclear factor-κB (NF-κB) activity. Furthermore, complex 1 inhibited angiogenesis in human umbilical vein endothelial cells (HUVECs) as revealed by an endothelial tube formation assay. This study demonstrates that kinetically inert rhodium(III) complexes may be potentially developed as effective anti-angiogenic agents. 

KeywordAngiogenesis Metal Complex Nf-κb Nitric Oxide Rhodium
DOI10.1016/j.jinorgbio.2014.06.020
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Inorganic & Nuclear
WOS IDWOS:000342608900004
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Cited Times [WOS]:12   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorMa D.-L.; Leung C.-H.
Affiliation1.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
2.Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China
3.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Liu L.-J.,Lin S.,Chan D.S.-H.,et al. A rhodium(III) complex inhibits LPS-induced nitric oxide production and angiogenic activity in cellulo[J]. Journal of Inorganic Biochemistry,2014,140:23-28.
APA Liu L.-J..,Lin S..,Chan D.S.-H..,Vong C.T..,Hoi P.M..,...&Leung C.-H..(2014).A rhodium(III) complex inhibits LPS-induced nitric oxide production and angiogenic activity in cellulo.Journal of Inorganic Biochemistry,140,23-28.
MLA Liu L.-J.,et al."A rhodium(III) complex inhibits LPS-induced nitric oxide production and angiogenic activity in cellulo".Journal of Inorganic Biochemistry 140(2014):23-28.
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