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Effect of extracts from Ilex hainanensis Merr. on human platelet aggregation in vitro
Li H.-Y.1; Meng L.-Z.1; Huang W.-H.1; Zhao J.1; Liu H.-G.2; Li S.-P.1
2013-06-01
Source PublicationChinese Journal of Pharmaceutical Biotechnology
ISSN10058915
Volume20Issue:3Pages:238-240
AbstractIlex hainanensis Merr is the national minority folk herbal medicine in the Guangxi Zhuang Autonomous Region, and its effects of blood invigorate and pulse promotion can provide potential therapeutic approaches to treatment cardiovascular diseases. The aim of this paper is to observe the effect of different extracts from Ilex hainanensis Merr (IHE) on human platelet aggregation induced by arachidonic acid sodium salt (AA), adenosine diphosphate (ADP), and epinephrine hydrochlaride (ADR), respectively, in, vitro. In this study, aspirin was used as positive control drug to establish the in vitro anti-platelet aggregation model and platelet aggregation rate was measured by Born's method. Platelet-rich plasma was collected from healthy donors and induced by AA, ADP and ADR, respectively and the model was applied to study the effect of different IHE on the platelet aggregation. The results showed that aspirin can significantly inhibit platelet aggregation induced by AA, ADP and ADR in vitro, respectively, but the IHE did not show inhibiting effect on the human platelet aggregation significantly. However, the IHE negative results can provide solid experimental evidence for improving drug quality standard.
KeywordAdenosine diphosphate Epinephrine hydrochloride Human body model Ilex hainanensis Merr Platelet aggregation: Aspirin: Rachidonic acid sodium salt
URLView the original
Language英語English
Fulltext Access
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Traditional Chinese Medicine
2.Guangxi Medical University
3.University of Macau
Recommended Citation
GB/T 7714
Li H.-Y.,Meng L.-Z.,Huang W.-H.,et al. Effect of extracts from Ilex hainanensis Merr. on human platelet aggregation in vitro[J]. Chinese Journal of Pharmaceutical Biotechnology,2013,20(3):238-240.
APA Li H.-Y.,Meng L.-Z.,Huang W.-H.,Zhao J.,Liu H.-G.,&Li S.-P..(2013).Effect of extracts from Ilex hainanensis Merr. on human platelet aggregation in vitro.Chinese Journal of Pharmaceutical Biotechnology,20(3),238-240.
MLA Li H.-Y.,et al."Effect of extracts from Ilex hainanensis Merr. on human platelet aggregation in vitro".Chinese Journal of Pharmaceutical Biotechnology 20.3(2013):238-240.
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