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cDNA microarray analysis of early gene expression profiles associated with hepatitis B virus X protein-mediated hepatocarcinogenesis
Ng R.K.; Lau C.Y.L.; Lee S.M.Y.; Tsui S.K.W.; Fung K.P.; Waye M.M.Y.
2004-09-24
Source PublicationBiochemical and Biophysical Research Communications
ISSN0006291X
Volume322Issue:3Pages:827-835
Abstract

Chronic hepatitis B virus (HBV) infection is one of the major causes of hepatocellular carcinoma. HBV encodes an oncogenic hepatitis B virus X protein (HBx), which can transactivate host cell transcriptional machinery and mediate cellular transformation. To disclose the early genetic response in HBx-mediated transformation process, we constructed a conditional HBx-expressing hepatocyte cell line, which allows us to compare the gene expression profiles under controllable HBx induction. A cDNA microarray containing more than 8700 mouse genes and ESTs was utilized to examine the gene expression profiles. We identified 260 candidate genes and 259 ESTs which have shown aberrant expression under HBx induction. Most of them are involved in signal transduction pathway, cell cycle control, metastasis, transcriptional regulation, immune response, and metabolism. These results provide additional insight into early cellular targets of HBx, which could give us a better understanding of the function of HBx and their progressive changes during HBx-mediated hepatocarcinogenesis. © 2004 Elsevier Inc. All rights reserved.

KeywordGene Expression Hbx Protein Hepatitis b Virus Hepatocellular Carcinoma Microarray Analysis
DOI10.1016/j.bbrc.2004.07.188
URLView the original
Indexed BySCIE
WOS Research AreaBiochemistry & Molecular Biology ; Biophysics
WOS SubjectBiochemistry & Molecular Biology ; Biophysics
WOS IDWOS:000223710500018
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Cited Times [WOS]:34   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationChinese University of Hong Kong
Recommended Citation
GB/T 7714
Ng R.K.,Lau C.Y.L.,Lee S.M.Y.,et al. cDNA microarray analysis of early gene expression profiles associated with hepatitis B virus X protein-mediated hepatocarcinogenesis[J]. Biochemical and Biophysical Research Communications,2004,322(3):827-835.
APA Ng R.K.,Lau C.Y.L.,Lee S.M.Y.,Tsui S.K.W.,Fung K.P.,&Waye M.M.Y..(2004).cDNA microarray analysis of early gene expression profiles associated with hepatitis B virus X protein-mediated hepatocarcinogenesis.Biochemical and Biophysical Research Communications,322(3),827-835.
MLA Ng R.K.,et al."cDNA microarray analysis of early gene expression profiles associated with hepatitis B virus X protein-mediated hepatocarcinogenesis".Biochemical and Biophysical Research Communications 322.3(2004):827-835.
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