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Cytoprotection of baicalein against oxidative stress-induced cardiomyocytes injury through the Nrf2/Keap1 pathway
Cui, Guozhen1; Chui Wah Luk, Sharon1; Li, Ronald Adolphus3; Chan, Ken Kwok Keung3; Lei, Si Wan1; Wang, Liang1; Shen, Huifang2; Leung, George Pak Heng4; Lee, Simon Ming Yuen1
2015
Source PublicationJournal of Cardiovascular Pharmacology
ISSN15334023 01602446
Volume65Issue:1Pages:39-46
Abstract

Baicalein is one of the major flavonoids found in the root of Scutellaria baicalensis Georgi. Previous studies suggest that baicalein displays protective effect on experimental cardiac models in vitro and in vivo. However, the mode of action remains unclear. Here, we showed that baicalein conferred cardioprotective effect against oxidative stress-induced cell injury in H9c2 cells and human embryonic stem cells-derived cardiomyocytes. Immunoprecipitation with anti-NF-E2-related factor 2 (Nrf2) antibody in baicalein-treated cells demonstrated that baicalein effectively disrupted the association between Nrf2 and Kelch-like epichlorohydrin-associated protein 1 (Keap1). In addition, the unbounded Nrf2 translocated from cytoplasm to nucleus and increased Nrf2/heme oxygenase-1 (HO-1) content in a time-dependent manner. Moreover, antioxidant response element transcriptional activity was enhanced by baicalein treatment, and the Nrf2 siRNA transfection could block the cytoprotective effect of baicalein. Taken together, these results demonstrate that baicalein protected cardiomyocytes against oxidative stress-induced cell injury through the Nrf2/Keap1 pathway.

KeywordBaicalein Cardioprotection Nrf2 Oxidative Stress
DOI10.1097/FJC.0000000000000161
URLView the original
Language英语
WOS Research AreaCardiovascular System & Cardiology ; Pharmacology & Pharmacy
WOS SubjectCardiac & Cardiovascular Systems ; Pharmacology & Pharmacy
WOS IDWOS:000348412000006
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Cited Times [WOS]:33   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLeung, George Pak Heng; Lee, Simon Ming Yuen
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
2.Department of Bioengineering, Zhuhai Campus of Zunyi Medical University, Zhuhai, China
3.Stem Cell and Regenerative Medicine Consortium, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
4.Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Cui, Guozhen,Chui Wah Luk, Sharon,Li, Ronald Adolphus,et al. Cytoprotection of baicalein against oxidative stress-induced cardiomyocytes injury through the Nrf2/Keap1 pathway[J]. Journal of Cardiovascular Pharmacology,2015,65(1):39-46.
APA Cui, Guozhen.,Chui Wah Luk, Sharon.,Li, Ronald Adolphus.,Chan, Ken Kwok Keung.,Lei, Si Wan.,...&Lee, Simon Ming Yuen.(2015).Cytoprotection of baicalein against oxidative stress-induced cardiomyocytes injury through the Nrf2/Keap1 pathway.Journal of Cardiovascular Pharmacology,65(1),39-46.
MLA Cui, Guozhen,et al."Cytoprotection of baicalein against oxidative stress-induced cardiomyocytes injury through the Nrf2/Keap1 pathway".Journal of Cardiovascular Pharmacology 65.1(2015):39-46.
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