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Protective Effect of Edaravone in Primary Cerebellar Granule Neurons against Iodoacetic Acid-Induced Cell Injury
Xinhua Zhou1; Longjun Zhu1; Liang Wang1,2; Baojian Guo1; Gaoxiao Zhang1; Yewei Sun1; Zaijun Zhang1; Simon Ming-Yuen Lee2; Pei Yu1; Yuqiang Wang1
2015
Source PublicationOxidative Medicine and Cellular Longevity
ISSN19420994 19420900
Volume2015
Abstract

Edaravone (EDA) is clinically used for treatment of acute ischemic stroke in Japan and China due to its potent free radical-scavenging effect. However, it has yet to be determined whether EDA can attenuate iodoacetic acid- (IAA-) induced neuronal death in vitro. In the present study, we investigated the effect of EDA on damage of IAA-induced primary cerebellar granule neurons (CGNs) and its possible underlying mechanisms. We found that EDA attenuated IAA-induced cell injury in CGNs. Moreover, EDA significantly reduced intracellular reactive oxidative stress production, loss of mitochondrial membrane potential, and caspase 3 activity induced by IAA. Taken together, EDA protected CGNs against IAA-induced neuronal damage, which may be attributed to its antiapoptotic and antioxidative activities.

DOI10.1155/2015/606981
URLView the original
Language英语
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000365573500001
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy, Guangzhou 510632, China
2.State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Avenue Padre Tomás Pereira S.J., Macau
Recommended Citation
GB/T 7714
Xinhua Zhou,Longjun Zhu,Liang Wang,et al. Protective Effect of Edaravone in Primary Cerebellar Granule Neurons against Iodoacetic Acid-Induced Cell Injury[J]. Oxidative Medicine and Cellular Longevity,2015,2015.
APA Xinhua Zhou,Longjun Zhu,Liang Wang,Baojian Guo,Gaoxiao Zhang,Yewei Sun,Zaijun Zhang,Simon Ming-Yuen Lee,Pei Yu,&Yuqiang Wang.(2015).Protective Effect of Edaravone in Primary Cerebellar Granule Neurons against Iodoacetic Acid-Induced Cell Injury.Oxidative Medicine and Cellular Longevity,2015.
MLA Xinhua Zhou,et al."Protective Effect of Edaravone in Primary Cerebellar Granule Neurons against Iodoacetic Acid-Induced Cell Injury".Oxidative Medicine and Cellular Longevity 2015(2015).
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