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Chemical and pharmacological evaluations on the extract of Scutellaria baicalensis Georgi (Huang-Qin) prepared by various extraction methods
Xuelin Zhou1; Pou Seng Choi2; Jia-Ming Yang3; Penelope M. Y. Or1; Pui Man Hoi2; Simon M. Y. Lee2; George P. H. Leung4; Sai Ming Ngai5; Siu Kai Kong5; Ho Pui Ho6; Melody Y. M. Wong7; Shun Wan Chan8; John H. K. Yeung1; Yiu Wa Kwan1
2016-08-30
Source PublicationSpringerPlus
ISSN2193-1801
Volume5Issue:1
Abstract

Background: This study reported a comprehensive approach (comparing the extraction yields, chemical profiles, antioxidant properties and CYP450-inhibitory effects) to evaluated the effectiveness of various extraction methods [microwave-assisted extraction using water (MAE-W), heat reflux extraction using water (HRE-W), ultrasonic extraction using 70 % ethanol and ultrasonic extraction using ethanol (UE-E)] for Huang-Qin (HQ), the dried root of Scutellaria baicalensis Georgi. Results: The HQ extraction efficiency by MAE-W was the best. The chemical profiles of extracts obtained using HRE-W and MAE-W were similar; whereas more flavones but less flavone glycosides were detected in the UE-E extract. There was no difference in the antioxidant properties among different extracts. In vitro human liver microsome assays illustrated that all extracts possessed herb–drug interaction potentials but the UE-E extract are shown with a potent interaction with CYP3A4-metabolized drugs. Conclusion: MAE-W is a favorable method for the preparation of HQ extracts based on extraction yield, pharmacological properties and safety.

KeywordAntioxidant Properties Extraction Efficiency Herb–drug Interaction Scutellaria Baicalensis Georgi
DOI10.1186/s40064-016-3115-3
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000391794700010
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorShun Wan Chan; John H. K. Yeung; Yiu Wa Kwan
Affiliation1.School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
2.Institute of Chinese Medical Sciences, University of Macau, Macao, China
3.School of Chinese Medicine, Faculty of Sciences, The Chinese University of Hong Kong, Hong Kong, China
4.Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, China
5.School of Life Sciences, Faculty of Sciences, The Chinese University of Hong Kong, Hong Kong, China
6.Department of Electronic Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Hong Kong, China
7.State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China
8.Department of Food and Health Sciences, Faculty of Science and Technology, The Technological and Higher Education Institute of Hong Kong, Hong Kong, China
Corresponding Author AffilicationFaculty of Science and Technology
Recommended Citation
GB/T 7714
Xuelin Zhou,Pou Seng Choi,Jia-Ming Yang,et al. Chemical and pharmacological evaluations on the extract of Scutellaria baicalensis Georgi (Huang-Qin) prepared by various extraction methods[J]. SpringerPlus,2016,5(1).
APA Xuelin Zhou,Pou Seng Choi,Jia-Ming Yang,Penelope M. Y. Or,Pui Man Hoi,Simon M. Y. Lee,George P. H. Leung,Sai Ming Ngai,Siu Kai Kong,Ho Pui Ho,Melody Y. M. Wong,Shun Wan Chan,John H. K. Yeung,&Yiu Wa Kwan.(2016).Chemical and pharmacological evaluations on the extract of Scutellaria baicalensis Georgi (Huang-Qin) prepared by various extraction methods.SpringerPlus,5(1).
MLA Xuelin Zhou,et al."Chemical and pharmacological evaluations on the extract of Scutellaria baicalensis Georgi (Huang-Qin) prepared by various extraction methods".SpringerPlus 5.1(2016).
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