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Enhanced in vitro and in vivo uptake of a hydrophobic model drug coumarin-6 in the presence of cucurbit[7]uril
Xiaoqing Miao2; Ye Li2; Ian Wyman1; Simon M. Y. Lee2; Donal H. Macartney1; Ying Zheng2; Ruibing Wang2
2015-07-01
Source PublicationMedChemComm
ISSN20402511 20402503
Volume6Issue:7Pages:1370-1374
Abstract

This report describes, for the first time, cucurbit[7]uril-assisted quantitative in vitro and in vivo uptake of a hydrophobic model drug, coumarin-6, by both an epithelial cell model and a zebrafish model. The transcellular delivery pathway study suggested multiple mechanisms involved, including macropinocytosis, clathrin and lipid raft-mediated endocytosis/exocytosis.

DOI10.1039/c5md00189g
URLView the original
Indexed BySCI
WOS Research AreaBiochemistry & Molecular Biology ; Pharmacology & Pharmacy
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Medicinal
WOS IDWOS:000357786200019
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Cited Times [WOS]:41   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYing Zheng; Ruibing Wang
Affiliation1.Department of Chemistry, Queen's University, Kingston, ON, Canada
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Xiaoqing Miao,Ye Li,Ian Wyman,et al. Enhanced in vitro and in vivo uptake of a hydrophobic model drug coumarin-6 in the presence of cucurbit[7]uril[J]. MedChemComm,2015,6(7):1370-1374.
APA Xiaoqing Miao.,Ye Li.,Ian Wyman.,Simon M. Y. Lee.,Donal H. Macartney.,...&Ruibing Wang.(2015).Enhanced in vitro and in vivo uptake of a hydrophobic model drug coumarin-6 in the presence of cucurbit[7]uril.MedChemComm,6(7),1370-1374.
MLA Xiaoqing Miao,et al."Enhanced in vitro and in vivo uptake of a hydrophobic model drug coumarin-6 in the presence of cucurbit[7]uril".MedChemComm 6.7(2015):1370-1374.
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