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A long-lifetime iridium(III) complex for lysosome tracking with high specificity and a large Stokes shift
Liu, Jin-Biao1,2; Vellaisamy, Kasipandi2; Li, Guodong3; Yang, Chao3; Wong, Suk-Yu2; Leung, Chung-Hang3; Pu, Shou-Zhi1; Ma, Dik-Lung2
2018-06-21
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
Volume6Issue:23Pages:3855-3858
Abstract

Investigating the role of lysosome dysfunction in cancer requires the development of efficient probes for lysosomes. We report herein a cyclometalated iridium(iii) complex (Ir-Ly) as a luminescent probe for visualizing lysosomes in cancer cells. The morpholine and hydroxy moieties within Ir-Ly provide suitable hydrophilicity and responsiveness to pH. Importantly, Ir-Ly exhibits a large Stokes shift, long lifetime and high photostability, which are important advantages for lysosome tracking in living cells.

DOI10.1039/c8tb00666k
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, bioMaterials
WOS IDWOS:000435351200002
PublisherROYAL SOC CHEMISTRY
The Source to ArticleWOS
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Cited Times [WOS]:13   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorMa, Dik-Lung
Affiliation1.Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang, China
2.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, China
3.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
Recommended Citation
GB/T 7714
Liu, Jin-Biao,Vellaisamy, Kasipandi,Li, Guodong,et al. A long-lifetime iridium(III) complex for lysosome tracking with high specificity and a large Stokes shift[J]. JOURNAL OF MATERIALS CHEMISTRY B,2018,6(23):3855-3858.
APA Liu, Jin-Biao,Vellaisamy, Kasipandi,Li, Guodong,Yang, Chao,Wong, Suk-Yu,Leung, Chung-Hang,Pu, Shou-Zhi,&Ma, Dik-Lung.(2018).A long-lifetime iridium(III) complex for lysosome tracking with high specificity and a large Stokes shift.JOURNAL OF MATERIALS CHEMISTRY B,6(23),3855-3858.
MLA Liu, Jin-Biao,et al."A long-lifetime iridium(III) complex for lysosome tracking with high specificity and a large Stokes shift".JOURNAL OF MATERIALS CHEMISTRY B 6.23(2018):3855-3858.
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