Status已發表Published
Affiliated with RCfalse
Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells
Li, Ying-Bo1,2; Zhong, Zhang-Feng1; Chen, Mei-Wan1; Bao, Jiao-Lin1; Wu, Guo-Sheng1; Zhang, Qing-Wen1; Lee, Simon Ming-Yuen1; Hoi, Pui-Man1; Wang, Yi-Tao1
2013-09-02
Source PublicationEVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 文献号: 851714
ISSN1741-427X
Volume2013
Abstract

Curcuminoids are well known for their capabilities to combat risk factors that are associated with ageing and cellular senescence. Recent reports have demonstrated that curcuminoids can extend the lifespan of model organisms. However, the underlying mechanisms by which these polyphenic compounds exert these beneficial effects remain unknown. In this study, t-BHP-induced premature senescence model in human fibroblasts was chosen to explore the protective effects of a curcuminoid, bisdemethoxycurcumin (BDMC), on cellular senescence. The results demonstrated that BDMC attenuated oxidative stress-induced senescence-like features which include the induction of an enlarged cellular appearance, higher frequency of senescence-associated beta-galactosidase staining activity, appearance of senescence-associated heterochromatic foci in nuclei, decrease in proliferation capability, and alteration inrelated molecules such as p16 and retinoblastoma protein. Notably, we found that BDMC treatment activated Sirt1/AMPK signaling pathway. Moreover, downregulating Sirt1 by the pharmacological inhibitor nicotianamine or small interfering RNA blocked BDMC-mediated protection against t-BHP-mediated decrease in proliferation. These results suggested that BDMC prevented t-BHP-induced cellular senescence, and BDMC-induced Sirt1 may be a mechanism mediating its beneficial effects.

DOI10.1155/2013/851714
Indexed BySCIE
Language英語English
WOS Research AreaIntegrative & Complementary Medicine
WOS SubjectIntegrative & Complementary Medicine
WOS IDWOS:000324438200001
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionTHE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU)
Corresponding AuthorHoi, Pui-Man; Wang, Yi-Tao
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenue Padre Tomás Pereira S.J., Taipa 999078, Macau
2.State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Li, Ying-Bo,Zhong, Zhang-Feng,Chen, Mei-Wan,et al. Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 文献号: 851714,2013,2013.
APA Li, Ying-Bo,Zhong, Zhang-Feng,Chen, Mei-Wan,Bao, Jiao-Lin,Wu, Guo-Sheng,Zhang, Qing-Wen,Lee, Simon Ming-Yuen,Hoi, Pui-Man,&Wang, Yi-Tao.(2013).Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 文献号: 851714,2013.
MLA Li, Ying-Bo,et al."Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 文献号: 851714 2013(2013).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, Ying-Bo]'s Articles
[Zhong, Zhang-Feng]'s Articles
[Chen, Mei-Wan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, Ying-Bo]'s Articles
[Zhong, Zhang-Feng]'s Articles
[Chen, Mei-Wan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, Ying-Bo]'s Articles
[Zhong, Zhang-Feng]'s Articles
[Chen, Mei-Wan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.