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“Ox-LDL-LOX-1-ROS” Signaling Pathway Involvement in Foam Cell Formation
Chen Xiuping; Zhao Haiyu; Zhong Zhangfeng; Xu Zengtao; Wang Yitao
2010
Source PublicationChinese Journal of Arteriosclerosis
Volume18Issue:7Pages:577-581
Abstract

Atherosclerosis is a multifactorial chronic vascular inflammatory disease characterized by lipid deposition and even lipid plaque formation in the vascular intima. Macrophage cholesterol accumulation and foam cell formation are the hallmarks of early atherogenesis. However, the underlying mechanisms of foam cell formation are not fully elucidated. Herein,we hypothesize that the signaling model composed of the oxidized low density lipoprotein(ox-LDL), the lectin-like oxidized low density lipoprotein receptor-1(LOX-1)and the reactive oxygen species(ROS) plays an important role in foam cell formation. In this model,ox-LDL is the activating factor;LOX-1, the main ox-LDL receptor expressed in endothelial cells, acts as a signal transducer while the ROS,a direct product of ox-LDL binding with LOX-1,is regarded as a catalyst and an inducer

KeywordAtherosclerosis Oxidized Low Density Lipoprotein Lectin-like Oxidized Low Density Lipoprotein Receptor-1 Reactive Oxygen Species Foam Cell Formation
DOI1007-3949(2010)18:7<577:YHXDMD>2.0.TX;2-6
Language英语
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Chen Xiuping, Institute of Chinese Medical Sciences, University of Macau, Macau.
2.Zhao Haiyu, Institute of Chinese Medical Sciences, University of Macau, Macau.
3.Zhong Zhangfeng, Institute of Chinese Medical Sciences, University of Macau, Macau.
4.Xu Zengtao, Institute of Chinese Medical Sciences, University of Macau, Macau.
5.Wang Yitao, Institute of Chinese Medical Sciences, University of Macau, Macau.
Recommended Citation
GB/T 7714
Chen Xiuping,Zhao Haiyu,Zhong Zhangfeng,et al. “Ox-LDL-LOX-1-ROS” Signaling Pathway Involvement in Foam Cell Formation[J]. Chinese Journal of Arteriosclerosis,2010,18(7):577-581.
APA Chen Xiuping,Zhao Haiyu,Zhong Zhangfeng,Xu Zengtao,&Wang Yitao.(2010).“Ox-LDL-LOX-1-ROS” Signaling Pathway Involvement in Foam Cell Formation.Chinese Journal of Arteriosclerosis,18(7),577-581.
MLA Chen Xiuping,et al."“Ox-LDL-LOX-1-ROS” Signaling Pathway Involvement in Foam Cell Formation".Chinese Journal of Arteriosclerosis 18.7(2010):577-581.
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