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Rapid HPLC-ESI-MS/MS for qualitative and quantitative analysis of saponins in "XUESETONG" injection
Lai, CM; Li, SP; Yu, H; Wan, JB; Kan, KW; Wang, YT

'XUESETONG' injection, one of the most widely used proprietary medicines in traditional Chinese medicine, consists of total saponins made from Panax notoginseng, which is a highly valued and important Chinese medicinal herb. It is used to treat cardiovascular diseases. In order to control the quality ofXUESETONG injection, a rapid HPLC-ESI-MS/MS method was developed for qualitative and quantitative determination of the saponins. The analyses were performed on SB-C18 column using gradient elution in 25 min. Full scan and time programmed selected reaction monitoring (SRM) were used for qualitativeand quantitative analysis of saponins, respectively. Twenty-seven saponins were identified and nine of them including notoginsenoside R1, ginsenoside Rb1, Rb2, Rb3, Rc, Rd, Re, Rf and Rg1 were quantified. Ten XUESETONG injections were analyzed and compared. The results showed that there is a great variation among different samples. In conclusion, the developed method is rapid, accurate and sensitive for qualitative and quantitative analysis of saponins inXUESETONG injection. Moreover, it also can be used for the quality control of P notoginseng raw material and its preparations. (c) 2005 Elsevier B.V. All rights reserved.

KeywordXuesetong Injection Panax Notoginseng Total Saponins Hplc-esi-ms/ms Notoginsenoside Ginsenoside Quality Control
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Indexed BySCIE
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Analytical ; Pharmacology & Pharmacy
WOS IDWOS:000235821100023
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Cited Times [WOS]:47   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationUniv Macau, Inst Chinese Med Sci, Taipa, Peoples R China
First Author AffilicationUniversity of Macau
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GB/T 7714
Lai, CM,Li, SP,Yu, H,et al. Rapid HPLC-ESI-MS/MS for qualitative and quantitative analysis of saponins in "XUESETONG" injection[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2006,40(3):669-678.
APA Lai, CM,Li, SP,Yu, H,Wan, JB,Kan, KW,&Wang, YT.(2006).Rapid HPLC-ESI-MS/MS for qualitative and quantitative analysis of saponins in "XUESETONG" injection.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,40(3),669-678.
MLA Lai, CM,et al."Rapid HPLC-ESI-MS/MS for qualitative and quantitative analysis of saponins in "XUESETONG" injection".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 40.3(2006):669-678.
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