UM  > Institute of Chinese Medical Sciences
Interference of Quercetin on Astragalus Polysaccharide-Induced Macrophage Activation
Li, Zhi-Peng1; Liu, Hong-Bing1; Zhang, Quan-Wei1; Li, Li-Feng1; Bao, Wan-Rong1; Ma, Dik-Lung2; Leung, Chung-Hang3; Bian, Zhao-Xiang1; Lu, Ai-Ping1; Han, Quan-Bin1
Source PublicationMOLECULES

Polysaccharides, which exert immunoregulatory effects, are becoming more and more popular as food supplements; however, certain components of ordinary foods could be reducing the polysaccharides beneficial effects. Quercetin, a flavonoid found in common fruits and vegetables, is one such component. This study investigated the effects of quercetin on Astragalus polysaccharide RAP induced-macrophage activation. The results show quercetin decreases the NO production and iNOS gene expression in RAW264.7 cells, and it inhibits the production of cytokines in RAW264.7 cells and peritoneal macrophages. Western blot analysis results suggest that quercetin inhibits the phosphorylation of Akt/mTORC1, MAPKs, and TBK1, but has no effect on NF-kappa B in RAP-induced RAW264.7 cells. Taken together, the results show that quercetin partly inhibits macrophage activation by the Astragalus polysaccharide RAP. This study demonstrates that quercetin-containing foods may interfere with the immune-enhancing effects of Astragalus polysaccharide RAP to a certain extent.

KeywordAstragalus Polysaccharide Quercetin Cytokines Macrophage Foods
URLView the original
Indexed BySCIE
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000445301800066
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China
2.Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China
3.University of Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China
Recommended Citation
GB/T 7714
Li, Zhi-Peng,Liu, Hong-Bing,Zhang, Quan-Wei,et al. Interference of Quercetin on Astragalus Polysaccharide-Induced Macrophage Activation[J]. MOLECULES,2018,23(7).
APA Li, Zhi-Peng,Liu, Hong-Bing,Zhang, Quan-Wei,Li, Li-Feng,Bao, Wan-Rong,Ma, Dik-Lung,Leung, Chung-Hang,Bian, Zhao-Xiang,Lu, Ai-Ping,&Han, Quan-Bin.(2018).Interference of Quercetin on Astragalus Polysaccharide-Induced Macrophage Activation.MOLECULES,23(7).
MLA Li, Zhi-Peng,et al."Interference of Quercetin on Astragalus Polysaccharide-Induced Macrophage Activation".MOLECULES 23.7(2018).
Files in This Item: Download All
File Name/Size Publications Version Access License
10.3390_molecules230(1815KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, Zhi-Peng]'s Articles
[Liu, Hong-Bing]'s Articles
[Zhang, Quan-Wei]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, Zhi-Peng]'s Articles
[Liu, Hong-Bing]'s Articles
[Zhang, Quan-Wei]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, Zhi-Peng]'s Articles
[Liu, Hong-Bing]'s Articles
[Zhang, Quan-Wei]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 10.3390_molecules23071563.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.