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Progress in anti-neoplastic effects and mechanisms of dihydroartemisinin
Lu J.-J.; Huang M.-Q.; Chen X.-P.; Wang Y.-T.
2012
Source PublicationChinese Journal of Pharmacology and Toxicology
Volume26Issue:3Pages:397
AbstractDihydroartemisinin, an important artemisinin derivative, presents excellent anti-neoplastic potential. This article reviews the latest progress in the anti-cancer activity of dihydroartemisinin and the possible mechanisms including anti-proliferation, cell cycle arrest, apoptosis induction, anti-angiogenesis and anti-metastasis. Iron (II) or heme may be the direct target for dihydroartemisinin. The broad anti-cancer spectrum, the low toxicity to normal cells and the potential of anti-multi-drug resistant cells make it a likely new anti-cancer candidate compound.
KeywordAntineoplastic agents Cell proliferation Dihydroartemisinin Neoangiogenesis Tumor metastasis
DOI10.3867/j.issn.1000-3002.2012.03.027
URLView the original
Language中文
The Source to ArticleScopus
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, 999078, Macau
2.Institute of Chinese Medical Sciences, University of Macau, 999078, Macau
3.College of Life Sciences, Zhejiang Chinese Medicine University, Hangzhou 310053, China
4.College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China
Recommended Citation
GB/T 7714
Lu J.-J.,Huang M.-Q.,Chen X.-P.,et al. Progress in anti-neoplastic effects and mechanisms of dihydroartemisinin[J]. Chinese Journal of Pharmacology and Toxicology,2012,26(3):397.
APA Lu J.-J.,Huang M.-Q.,Chen X.-P.,&Wang Y.-T..(2012).Progress in anti-neoplastic effects and mechanisms of dihydroartemisinin.Chinese Journal of Pharmacology and Toxicology,26(3),397.
MLA Lu J.-J.,et al."Progress in anti-neoplastic effects and mechanisms of dihydroartemisinin".Chinese Journal of Pharmacology and Toxicology 26.3(2012):397.
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