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Enantiomeric separation of angular-type pyranocoumarins from Peucedani Radix using AD-RH chiral column
Song Y.-L.; Jing W.-H.; Tu P.-F.; Wang Y.-T.
2014
Source PublicationNatural Product Research
Volume28Issue:8Pages:545
Abstract

Enantiomers and diastereoisomers of angular-type pyranocoumarins (APs) are abundant in Peucedani Radix (Chinese name: Qian-hu), eliciting distinct activities in vitro and in vivo. Our ongoing investigation on APs yielded eight pairs of enantiomers (1a and 1b, 2a and 2b, 3a and 3b, 4a and 4b, 5a and 5b, 6a and 6b, 7a and 7b and 8a and 8b) via enantiomeric separation of trans-3′-angeloylkhellactone (1), trans-3′-acetyl-4′- isobutyrylkhellactone (2), trans-3′-acetyl-4′-angeloyl-khellactone (3), 3′-angeloyloxy-4′-oxo-3′,4′-dihydroseselin (4), cis-3′-acetyl-4′-angeloylkhellactone (5), cis-3′-isovaleryl- 4′-acetylkhellactone (6), cis-3′-angeloyl-4′- isovalerylkhellactone (7) and cis-3′,4′-diisovalerylkhellactone (8), respectively, using semi-preparative AD-RH chiral column. All the compounds (1-8) were enantioseparated for the first time, while the absolute configurations of 2a, 2b, 6a and 8b were reported first. © 2014 Taylor & Francis.

KeywordAbsolute Configuration Angular-type Pyranocoumarins Enantiomeric Separation Enantiomers Peucedani Radix
DOI10.1080/14786419.2014.883397
URLView the original
Indexed BySCIE
Language英语
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Applied ; Chemistry, Medicinal
WOS IDWOS:000334070700008
The Source to ArticleScopus
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, SAR, Macau
2.Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
3.State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
Recommended Citation
GB/T 7714
Song Y.-L.,Jing W.-H.,Tu P.-F.,et al. Enantiomeric separation of angular-type pyranocoumarins from Peucedani Radix using AD-RH chiral column[J]. Natural Product Research,2014,28(8):545.
APA Song Y.-L.,Jing W.-H.,Tu P.-F.,&Wang Y.-T..(2014).Enantiomeric separation of angular-type pyranocoumarins from Peucedani Radix using AD-RH chiral column.Natural Product Research,28(8),545.
MLA Song Y.-L.,et al."Enantiomeric separation of angular-type pyranocoumarins from Peucedani Radix using AD-RH chiral column".Natural Product Research 28.8(2014):545.
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