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The fingerprint of Ezhu by GC-MS
Yang F.-Q.1; Li S.-P.1; Chen Y.1; Liu Q.-Q..1; Wang Y.-T.1; Dong T.-X.2; Zhan H.-Q.2
Source PublicationYaoxue Xuebao

Aim: To study the fingerprint of Ezhu by GC-MS. Methods: GC-MS analysis was performed for 18 samples of three species of Curcuma used as Ezhu. TIC profiles were evaluated by "Computer Aided Similarity Evaluation System" (MATLAB5.3 based, Ver. 1.240, developed by Research Center for Modernization of Chinese Medicine, Central South University). The characteristic peaks in chromatograms were identified by comparing mass data with literatures. Hierarchical clustering analysis was performed by SPSS based on the relative peak area (RPA) of identified peak to germacrone in 18 samples. Results: Resemblance values of 18 samples of Ezhu were pretty low. The mutual mode fingerprint plots of Ezhu were failed to develop. However, 18 samples were divided into two main clusters based on hierarchical clustering analysis, Curcuma wenyujin cluster and Curcuma phaeocaulis cluster, but the samples of Curcuma kwangsiensis were dispersive. Therefore, based on hierarchical clustering analysis, two mutual mode fingerprint plots of Curcuma wenyujin and Curcuma phaeocaulis were developed. But that of Curcuma kwangsiensis was failed because of low resemblance among samples. Conclusion: The mutual mode fingerprint is the basis for quality control of Chinese materia medica from multi-origins. Development of GC-MS fingerprint of Ezhu was failed, which indicates that the chemical components in different species of herbs used as one Chinese materia medica may be significantly different. The relationship of chemical components and pharmacological activities should be further studied so as to elucidate the rationality of Chinese materia medica from multi-origins.

KeywordCurcuma Kwangsiensis Curcuma Phaeocaulis Curcuma Wenyujin Gc-ms Fingerprint Hierarchical Clustering Analysis Similarity
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Institute of Chinese Medical Sciences, University of Macau, Macau, China
2.Department of Biology and Biotechnology Research Institute, Hong Kong University of Science and Technology, Hong Kong, Hong Kong
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Yang F.-Q.,Li S.-P.,Chen Y.,et al. The fingerprint of Ezhu by GC-MS[J]. Yaoxue Xuebao,2005,40(11):1013.
APA Yang F.-Q.,Li S.-P.,Chen Y.,Liu Q.-Q..,Wang Y.-T.,Dong T.-X.,&Zhan H.-Q..(2005).The fingerprint of Ezhu by GC-MS.Yaoxue Xuebao,40(11),1013.
MLA Yang F.-Q.,et al."The fingerprint of Ezhu by GC-MS".Yaoxue Xuebao 40.11(2005):1013.
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