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Effect of resveratrol on proliferation and differentiation of embryonic cardiomyoblasts
Leong C.-W.; Wong C.H.; Lao S.-C.; Leong E.C.; Lao I.F.; Law P.T.W.; Fung K.P.; Tsang K.S.; Waye M.M.-Y.; Tsui S.K.-W.; Wang Y.-T.; Lee S.M.-Y.
2007
Source PublicationBiochemical and Biophysical Research Communications
Volume360Issue:1Pages:173
Abstract

Resveratrol (trans-3,5,4′-trihydroxystilbene), a polyphenolic compound found largely in the skins of red grapes, has been used as a nutritional supplement or an investigational new drug for prevention of cardiovascular diseases. Previous reports showed that resveratrol had a protective effect against oxidative agent-induced cell injury. Our studies indicate that resveratrol plays a role in the differentiation of cardiomyoblasts. The cardiomyoblast cell line, H9c2, was exposed to 30-120 μM resveratrol for up to 5 days. Resveratrol inhibits cardiomyoblast proliferation without causing cells injury. Moreover, resveratrol treatment modulated the differentiation of morphological characteristics including elongation and cell fusion in cardiomyoblasts. Proliferation and differentiation of H9c2 cells were further revealed by measurement of the mRNA expression of a cell cycle marker (CDK2), a differentiation marker (myogenin), and a contractile apparatus protein (MLC-2). Gene expression analysis revealed that resveratrol promoted entry into cell cycle arrest but extended the myogenic differentiation progress. These results have implications for the role of resveratrol in modulating cell cycle control and differentiation in cardiomyoblasts. © 2007 Elsevier Inc. All rights reserved.

KeywordCardiomyoblast Differentiation Resveratrol
DOI10.1016/j.bbrc.2007.06.025
URLView the original
Indexed BySCIE
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Biophysics
WOS SubjectBiochemistry & Molecular Biology ; Biophysics
WOS IDWOS:000248137400028
The Source to ArticleScopus
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Cited Times [WOS]:24   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao, China
2.Department of Biochemistry, The Chinese University of Hong Kong, Hong Kong, Hong Kong
3.Institute of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong
4.Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, Hong Kong
Recommended Citation
GB/T 7714
Leong C.-W.,Wong C.H.,Lao S.-C.,et al. Effect of resveratrol on proliferation and differentiation of embryonic cardiomyoblasts[J]. Biochemical and Biophysical Research Communications,2007,360(1):173.
APA Leong C.-W.,Wong C.H.,Lao S.-C.,Leong E.C.,Lao I.F.,Law P.T.W.,Fung K.P.,Tsang K.S.,Waye M.M.-Y.,Tsui S.K.-W.,Wang Y.-T.,&Lee S.M.-Y..(2007).Effect of resveratrol on proliferation and differentiation of embryonic cardiomyoblasts.Biochemical and Biophysical Research Communications,360(1),173.
MLA Leong C.-W.,et al."Effect of resveratrol on proliferation and differentiation of embryonic cardiomyoblasts".Biochemical and Biophysical Research Communications 360.1(2007):173.
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