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A cyclometallated iridium(III) complex as a c-myc G-Quadruplex stabilizer and down-regulator of c-myc oncogene expression
Yang H.1; Ma V.P.-Y.1; Chan D.S.-H.1; He H.-Z.1; Leung C.-H.2; Ma D.-L.1
2013
Source PublicationCurrent Medicinal Chemistry
ISSN9298673
Volume20Issue:4Pages:576-582
Abstract

A new cyclometallated iridium(III) complex with the 2,2'-biquinoline N-donor ligand has been synthesized and characterized. The interaction and affinity of the complex towards c-myc G-quadruplex and duplex DNA have been investigated using UV/Vis spectroscopy and gel mobility shift assay. These studies revealed that complex 1 binds to c-myc G-quadruplexes (Pu22 and Pu27) with high affinity but does not interact with duplex DNA either by intercalation or groove binding. The ability of 1 to stabilize c-myc G-quadruplex DNA in vitro has also been examined through a PCR stop assay and a cell-based luciferase reporter assay. Complex 1 displays promising cytotoxic activity against the HeLa cell line with sub-micromolar potency.

KeywordC-myc Dna G-quadruplex Iridium(Iii) Metal Complex Oncogene Promoter
DOI10.2174/0929867311320040009
URLView the original
Indexed BySCIE
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Pharmacology & Pharmacy
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000316608900009
The Source to ArticleScopus
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Cited Times [WOS]:16   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorMa D.-L.
Affiliation1.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
Recommended Citation
GB/T 7714
Yang H.,Ma V.P.-Y.,Chan D.S.-H.,et al. A cyclometallated iridium(III) complex as a c-myc G-Quadruplex stabilizer and down-regulator of c-myc oncogene expression[J]. Current Medicinal Chemistry,2013,20(4):576-582.
APA Yang H.,Ma V.P.-Y.,Chan D.S.-H.,He H.-Z.,Leung C.-H.,&Ma D.-L..(2013).A cyclometallated iridium(III) complex as a c-myc G-Quadruplex stabilizer and down-regulator of c-myc oncogene expression.Current Medicinal Chemistry,20(4),576-582.
MLA Yang H.,et al."A cyclometallated iridium(III) complex as a c-myc G-Quadruplex stabilizer and down-regulator of c-myc oncogene expression".Current Medicinal Chemistry 20.4(2013):576-582.
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