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Patient-Derived Organoids Can Guide Personalized-Therapies for Patients with Advanced Breast Cancer
Chen, Ping1,2,3,4; Zhang, Xu1,2; Ding, Renbo1,2; Yang, Linglin4; Lyu, Xueying1,2; Zeng, Jianming1,2; Lei, Josh Haipeng1,2; Wang, Lijian1,2; Bi, Jiong5; Shao, Nan6; Shu, Ditian7; Wu, Bin8; Wu, Jingbo4; Yang, Zhihui9; Wang, Haiyan8; Wang, Biqiong4; Xiong, Kang4; Lu, Yun4; Fu, Shaozhi4; Choi, Tak Kan1,2; Lon, Ng Wai10; Zhang, Aiping1,2; Tang, Dongyang1,2; Quan, Yingyao1,2,11; Meng, Ya11; Miao, Kai1,2,3; Sun, Heng1,2,3; Zhao, Ming1,2,4; Bao, Jiaolin1,2; Zhang, Lei1,2,12; Xu, Xiaoling1,2,3; Shi, Yanxia7; Lin, Ying6; Deng, Chuxia1,2,3
2021-11-01
Source PublicationAdvanced Science
ISSN2198-3844
Volume8Issue:22
Abstract

Most breast cancers at an advanced stage exhibit an aggressive nature, and there is a lack of effective anticancer options. Herein, the development of patient-derived organoids (PDOs) is described as a real-time platform to explore the feasibility of tailored treatment for refractory breast cancers. PDOs are successfully generated from breast cancer tissues, including heavily treated specimens. The microtubule-targeting drug-sensitive response signatures of PDOs predict improved distant relapse-free survival for invasive breast cancers treated with adjuvant chemotherapy. It is further demonstrated that PDO pharmaco-phenotyping reflects the previous treatment responses of the corresponding patients. Finally, as clinical case studies, all patients who receive at least one drug predicate to be sensitive by PDOs achieve good responses. Altogether, the PDO model is developed as an effective platform for evaluating patient-specific drug sensitivity in vitro, which can guide personal treatment decisions for breast cancer patients at terminal stage.

KeywordAdvanced Breast Cancer Drug Screening Patient-derived Organoids Personalized Therapy
DOI10.1002/advs.202101176
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000703008300001
Scopus ID2-s2.0-85116160765
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Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorShi, Yanxia; Lin, Ying; Deng, Chuxia
Affiliation1.Cancer Centre, Faculty of Health Sciences, University of Macau, 999078, Macao
2.Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, 999078, Macao
3.MOE Frontier Science Centre for Precision Oncology, University of Macau, 999078, Macao
4.Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China
5.Laboratory of Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, No. 58 of Zhongshan 2nd road, Yuexiu district, 510080, China
6.Breast Disease Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, No.58 of Zhongshan 2nd road, Yuexiu district, 510080, China
7.Department of Medical Oncology, Sun Yet-sen University Cancer Center, Collaborative Innovation Center of Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, 510060, China
8.Department of Breast Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China
9.Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China
10.Centro Hospitalar Conde de S. Januário, 999078, Macao
11.Zhuhai Interventional Medical Center, Zhuhai Precision Medical Center, Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai, 519000, China
12.Department of Vascular Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China
First Author AffilicationCancer Centre;  Faculty of Health Sciences;  University of Macau
Corresponding Author AffilicationCancer Centre;  Faculty of Health Sciences;  University of Macau
Recommended Citation
GB/T 7714
Chen, Ping,Zhang, Xu,Ding, Renbo,et al. Patient-Derived Organoids Can Guide Personalized-Therapies for Patients with Advanced Breast Cancer[J]. Advanced Science,2021,8(22).
APA Chen, Ping.,Zhang, Xu.,Ding, Renbo.,Yang, Linglin.,Lyu, Xueying.,Zeng, Jianming.,Lei, Josh Haipeng.,Wang, Lijian.,Bi, Jiong.,Shao, Nan.,Shu, Ditian.,Wu, Bin.,Wu, Jingbo.,Yang, Zhihui.,Wang, Haiyan.,Wang, Biqiong.,Xiong, Kang.,Lu, Yun.,Fu, Shaozhi.,...&Deng, Chuxia.(2021).Patient-Derived Organoids Can Guide Personalized-Therapies for Patients with Advanced Breast Cancer.Advanced Science,8(22).
MLA Chen, Ping,et al."Patient-Derived Organoids Can Guide Personalized-Therapies for Patients with Advanced Breast Cancer".Advanced Science 8.22(2021).
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