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Altered Neural Processing of Reward and Punishment in Women With Methamphetamine Use Disorder
Wei, Shuguang1; Xue, Zhaoxia2; Sun, Wujun3; Han, Jie4; Wu, Haiyan5; Liu, Xun6,7
2021-10-13
Source PublicationFrontiers in Psychiatry
Volume12
AbstractIt has been suggested that the altered function of reward and punishment is an important vulnerability factor leading to the development of drug use disorders. Previous studies have identified evidence of neurophysiological dysfunction in the reward process of individuals with substance use disorders. To date, only a few event-related potential (ERP) studies have examined the neural basis of reward and punishment processing in women with methamphetamine (MA) use disorders. The current ERP research aims to investigate the neurophysiological mechanisms of reward and punishment in women with MA use disorder using a monetary incentive delay task. Nineteen women with MA use disorder (MA group) and 20 healthy controls (HC group) were recruited in this study. The behavioral data showed that the reaction time (RT) was faster and the response accuracy (ACC) was higher for the potential reward and punishment conditions compared to neutral conditions. During the monetary incentive anticipation stage, the Cue-P3, and stimulus-preceding negativity (SPN) were larger in the MA group than in the HC group. The SPN under the potential reward condition was larger than that under the neutral condition in the MA group but not in the HC group. During the monetary incentive consummation stage, the feedback-related negativity and feedback P3 (FB-P3) following positive feedback were significantly larger than negative feedback in the potential reward condition for the HC group, but not for the MA group. However, the FB-P3 following negative feedback was significantly larger than positive feedback in the potential punishment condition for the MA group, but not the HC group. The results suggest that women with MUD have stronger expectations of generic reward and stronger response of generic harm avoidance, which could be targeted in designing interventions for women with MA use disorder.
KeywordCue-P3 feedback P3 (FB-P3) feedback-related negativity (FRN) methamphetamine (MA) use disorder punishment processing reward processing stimulus-preceding negativity (SPN)
DOI10.3389/fpsyt.2021.692266
URLView the original
Language英語English
Scopus ID2-s2.0-85118115978
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Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Department of Psychology, College of Education, Hebei Normal University, Shijiazhuang, China
2.Department of Applied Psychology, College of Humanities and Social Sciences, Shanxi Medical University, Taiyuan, China
3.Faculty of Education, Henan Normal University, Xinxiang, China
4.Hebei Female Drug Rehabilitation Center, Shijiazhuang, China
5.Centre for Cognitive and Brain Sciences and Department of Psychology, University of Macau, Macao
6.Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
7.Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
Recommended Citation
GB/T 7714
Wei, Shuguang,Xue, Zhaoxia,Sun, Wujun,et al. Altered Neural Processing of Reward and Punishment in Women With Methamphetamine Use Disorder[J]. Frontiers in Psychiatry,2021,12.
APA Wei, Shuguang,Xue, Zhaoxia,Sun, Wujun,Han, Jie,Wu, Haiyan,&Liu, Xun.(2021).Altered Neural Processing of Reward and Punishment in Women With Methamphetamine Use Disorder.Frontiers in Psychiatry,12.
MLA Wei, Shuguang,et al."Altered Neural Processing of Reward and Punishment in Women With Methamphetamine Use Disorder".Frontiers in Psychiatry 12(2021).
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