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Label-free luminescent switch-on probe for ochratoxin a detection using a G-quadruplex-selective iridium(III) complex
Lu L.1; Wang M.1; Liu L.-J.2; Leung C.-H.2; Ma D.-L.1,3
2015
Source PublicationACS Applied Materials and Interfaces
ISSN1944-8244
Volume7Issue:15Pages:8313
Abstract

A library of six luminescent Ir(III) complexes were synthesized and studied for their capacity to function as probes for G-quadruplex DNA. The novel Ir(III) complex 1 was discovered to be selective for G-quadruplex structures and was subsequently used for the construction of a label-free G-quadruplex-based ochratoxin A (OTA) sensing platform in aqueous solution. The assay exhibited linearity for OTA in the range of 0 to 60 nM (R2 = 0.9933), and the limit of detection for OTA was 5 nM. Furthermore, this assay was highly selective for OTA over its structurally related analogues. 

KeywordG-quadruplex Iridium(Iii) Complex Label-free Luminescent Ochratoxin a
DOI10.1021/acsami.5b01702
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000353607100058
The Source to ArticleScopus
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Cited Times [WOS]:39   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLeung C.-H.
Affiliation1.Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China
2.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China
3.Hong Kong Baptist Univ, Partner State Key Lab Environm & Biol Anal, Hong Kong, Hong Kong, Peoples R China
Corresponding Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Lu L.,Wang M.,Liu L.-J.,et al. Label-free luminescent switch-on probe for ochratoxin a detection using a G-quadruplex-selective iridium(III) complex[J]. ACS Applied Materials and Interfaces,2015,7(15):8313.
APA Lu L.,Wang M.,Liu L.-J.,Leung C.-H.,&Ma D.-L..(2015).Label-free luminescent switch-on probe for ochratoxin a detection using a G-quadruplex-selective iridium(III) complex.ACS Applied Materials and Interfaces,7(15),8313.
MLA Lu L.,et al."Label-free luminescent switch-on probe for ochratoxin a detection using a G-quadruplex-selective iridium(III) complex".ACS Applied Materials and Interfaces 7.15(2015):8313.
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