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The Extracts of Angelica sinensis and Cinnamomum cassia from Oriental Medicinal Foods Regulate Inflammatory and Autophagic Pathways against Neural Injury after Ischemic Stroke
Luo, Cheng1; Chen, Qi2; Liu, Bowen3; Wang, Shengpeng3; Yu, Hualin1; Guan, Xiaowei4; Zhao, Yonghua3; Wang, Yitao3
2021-06-28
Source PublicationOxidative Medicine and Cellular Longevity
ISSN1942-0900
Volume2021
Abstract

The study indicates inflammation and autophagy are closely related to neural apoptosis in the pathology of ischemic stroke. In the study, we investigate the effects and mechanisms of the extracts of Angelica sinensis and Cinnamomum cassia (AC) from oriental medicinal foods on inflammatory and autophagic pathways in rat permanent middle cerebral artery occlusion model. Three doses of AC extract were, respectively, administered for 7 days. It suggests that AC extract treatment ameliorated scores of motor and sensory functions and ratio of glucose utilization in thalamic lesions in a dose-dependent manner. Expression of Iba1 was decreased and CD206 was increased by immunofluorescence staining, western blotting results showed expressions of TLR4, phosphorylated-IKKβ and IκBα, nuclear P65, NLRP3, ASC, and Caspase-1 were downregulated, and Beclin 1 and LC3 II were upregulated. Low concentrations of TNF-α, IL-1β, and IL-6 were presented by ELISA assay. Additionally, caspase 8 and cleaved caspase-3 expressions and the number of TUNEL positive cells in ipsilateral hemisphere were decreased, while the ratio of Bcl-2/Bax was increased. Simultaneously, in LPS-induced BV2 cells, it showed nuclear P65 translocation and secretion of proinflammatory cytokines were suppressed by AC extract-contained cerebrospinal fluid, and its intervened effects were similar to TLR4 siRNA treatment. Our study demonstrates that AC extract treatment attenuates inflammatory response and elevates autophagy against neural apoptosis, which contributes to the improvement of neurological function poststroke. Therefore, AC extract may be a novel neuroprotective agent by regulation of inflammatory and autophagic pathways for ischemic stroke treatment.

DOI10.1155/2021/9663208
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000674620500008
Scopus ID2-s2.0-85110185139
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Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorZhao, Yonghua; Wang, Yitao
Affiliation1.Second Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming, China
2.Affiliated Hospital of Southwest Medical University, Luzhou, China
3.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, Macao
4.Department of Human Anatomy and Histoembryology, School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, China
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Luo, Cheng,Chen, Qi,Liu, Bowen,et al. The Extracts of Angelica sinensis and Cinnamomum cassia from Oriental Medicinal Foods Regulate Inflammatory and Autophagic Pathways against Neural Injury after Ischemic Stroke[J]. Oxidative Medicine and Cellular Longevity,2021,2021.
APA Luo, Cheng,Chen, Qi,Liu, Bowen,Wang, Shengpeng,Yu, Hualin,Guan, Xiaowei,Zhao, Yonghua,&Wang, Yitao.(2021).The Extracts of Angelica sinensis and Cinnamomum cassia from Oriental Medicinal Foods Regulate Inflammatory and Autophagic Pathways against Neural Injury after Ischemic Stroke.Oxidative Medicine and Cellular Longevity,2021.
MLA Luo, Cheng,et al."The Extracts of Angelica sinensis and Cinnamomum cassia from Oriental Medicinal Foods Regulate Inflammatory and Autophagic Pathways against Neural Injury after Ischemic Stroke".Oxidative Medicine and Cellular Longevity 2021(2021).
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