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Specific NLRP3 inflammasome inhibitors: promising therapeutic agents for inflammatory diseases
Vong, Chi Teng; Tseng, Hisa Hui Ling; Yao, Peifen; Yu, Hua; Wang, Shengpeng; Zhong, Zhangfeng; Wang, Yitao
2021-06-01
Source PublicationDrug Discovery Today
ISSN1359-6446
Volume26Issue:6Pages:1394-1408
Abstract

Innate immunity serves as a first line of defence against danger signals, invading pathogens and microbes. The inflammasomes, as pattern recognition receptors, sense these danger signals to initiate pro-inflammatory cascades. The nucleotide-binding domain leucine-rich repeat and pyrin domain containing receptor 3 (NLRP3) inflammasome is the most well characterised inflammasome, and its aberrant activation is implicated in many inflammatory diseases. In the past decade, targeting the NLRP3 inflammasome has become an emerging strategy for inflammatory diseases. To avoid off-target immunosuppressive effects, specific NLRP3 inhibitors have been developed and show promising therapeutic effects. This review discusses the therapeutic effects and clinical perspectives of specific NLRP3 inhibitors, as well as recent progress in the development of these inhibitors for the treatment of inflammatory diseases.

DOI10.1016/j.drudis.2021.02.018
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000664035500008
Scopus ID2-s2.0-85101675283
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorWang, Yitao
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Vong, Chi Teng,Tseng, Hisa Hui Ling,Yao, Peifen,et al. Specific NLRP3 inflammasome inhibitors: promising therapeutic agents for inflammatory diseases[J]. Drug Discovery Today,2021,26(6):1394-1408.
APA Vong, Chi Teng,Tseng, Hisa Hui Ling,Yao, Peifen,Yu, Hua,Wang, Shengpeng,Zhong, Zhangfeng,&Wang, Yitao.(2021).Specific NLRP3 inflammasome inhibitors: promising therapeutic agents for inflammatory diseases.Drug Discovery Today,26(6),1394-1408.
MLA Vong, Chi Teng,et al."Specific NLRP3 inflammasome inhibitors: promising therapeutic agents for inflammatory diseases".Drug Discovery Today 26.6(2021):1394-1408.
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