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Biomaterial-based physical regulation of macrophage behaviour
Zhou, Huiqun1; Xue, Yizebang1,2; Dong, Lei3; Wang, Chunming1
2021-05-07
Source PublicationJournal of Materials Chemistry B
ISSN2050-750X
Volume9Issue:17Pages:3608-3621
AbstractMacrophages play a critical role in regulating immune reactions induced by implanted biomaterials. They are highly plastic and in response to diverse stimuli in the microenvironment can exhibit a spectrum of phenotypes and functions. In addition to biochemical signals, the physical properties of biomaterials are becoming increasingly appreciated for their significant impact on macrophage behaviour, and the underlying mechanisms deserve more in-depth investigations. This review first summarises the effects of key physical cues - including stiffness, topography, physical confinement and applied force - on macrophage behaviour. Then, it reviews the current knowledge of cellular sensing and transduction of physical cues into intracellular signals. Finally, it discusses the major challenges in understanding mechanical regulation that could provide insights for biomaterial design.
DOI10.1039/d1tb00107h
URLView the original
Language英語English
Scopus ID2-s2.0-85105543219
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Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao
2.Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, China
3.State Key Laboratory of Pharmaceutical Biotechnology, Medical School & School of Life Sciences, Nanjing University, Nanjing, 210023, China
First Author AffilicationInstitute of Chinese Medical Sciences
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GB/T 7714
Zhou, Huiqun,Xue, Yizebang,Dong, Lei,et al. Biomaterial-based physical regulation of macrophage behaviour[J]. Journal of Materials Chemistry B,2021,9(17):3608-3621.
APA Zhou, Huiqun,Xue, Yizebang,Dong, Lei,&Wang, Chunming.(2021).Biomaterial-based physical regulation of macrophage behaviour.Journal of Materials Chemistry B,9(17),3608-3621.
MLA Zhou, Huiqun,et al."Biomaterial-based physical regulation of macrophage behaviour".Journal of Materials Chemistry B 9.17(2021):3608-3621.
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