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Corona-directed nucleic acid delivery into hepatic stellate cells for liver fibrosis therapy
Zhang Z.1; Wang C.2; Zha Y.1; Hu W.1; Gao Z.1; Zang Y.1; Chen J.1; Zhang J.1; Dong L.1
Source PublicationACS Nano

Strategies to modify nanoparticles with biological ligands for targeted drug delivery in vivo have been widely studied but met with limited clinical success. A possible reason is that, in the blood circulation, serum proteins could rapidly form a layer of protein "corona" on the vehicle surface, which might block the modified ligands and hamper their targeting functions. We speculate that strategies for drug delivery can be designed based upon elegant control of the corona formation on the vehicle surfaces. In this study, we demonstrate a retinol-conjugated polyetherimine (RcP) nanoparticle system that selectively recruited the retinol binding protein 4 (RBP) in its corona components. RBP was found to bind retinol, and direct the antisense oligonucleotide (ASO)-laden RcP carrier to hepatic stellate cells (HSC), which play essential roles in the progression of hepatic fibrosis. In both mouse fibrosis models, induced by carbon tetrachloride (CCl4) and bile duct ligation (BDL), respectively, the ASO-laden RcP particles effectively suppressed the expression of type I collagen (collagen I), and consequently ameliorated hepatic fibrosis. Such findings suggest that this delivery system, designed to exploit the power of corona proteins, can serve as a promising tool for targeted delivery of therapeutic agents for the treatment of hepatic fibrosis. © 2015 American Chemical Society.

KeywordDrug Nanocarriers Hepatic Fibrosis Protein Corona Retinol Targeted Delivery
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Indexed BySCI
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000351791800018
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Cited Times [WOS]:65   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorZhang J.; Dong L.
Affiliation1.State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China
Recommended Citation
GB/T 7714
Zhang Z.,Wang C.,Zha Y.,et al. Corona-directed nucleic acid delivery into hepatic stellate cells for liver fibrosis therapy[J]. ACS Nano,2015,9(3):2405.
APA Zhang Z..,Wang C..,Zha Y..,Hu W..,Gao Z..,...&Dong L..(2015).Corona-directed nucleic acid delivery into hepatic stellate cells for liver fibrosis therapy.ACS Nano,9(3),2405.
MLA Zhang Z.,et al."Corona-directed nucleic acid delivery into hepatic stellate cells for liver fibrosis therapy".ACS Nano 9.3(2015):2405.
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