UM  > Faculty of Health Sciences
Measurement-based care versus standard care for major depression: A randomized controlled trial with blind raters
Guo T.; Xiang Y.-T.; Xiao L.; Hu C.-Q.; Chiu H.F.K.; Ungvari G.S.; Correll C.U.; Lai K.Y.C.; Feng L.; Geng Y.; Feng Y.; Wang G.
Source PublicationAmerican Journal of Psychiatry

Objective: The authors compared measurement-based care with standard treatment in major depression. Methods: Outpatients with moderate to severe major depression were consecutively randomized to 24 weeks of either measurement-based care (guideline- and rating scalebased decisions; N=61), or standard treatment (clinicians? choice decisions; N=59). Pharmacotherapy was restricted to paroxetine (20?60mg/day) or mirtazapine (15?45mg/day) in both groups. Depressive symptoms were measured with the Hamilton Depression Rating Scale (HAM-D) and the Quick InventoryofDepressiveSymptomatology? Self-Report (QIDS-SR). Time to response (a decrease of at least 50% in HAM-Dscore) and remission (a HAM-D score of 7 or less) were the primary endpoints. Outcomes were evaluated by raters blind to study protocol and treatment. Results: Significantly more patients in the measurementbased care group than in the standard treatment group achieved response (86.9% compared with 62.7%) and remission (73.8% compared with 28.8%). Similarly, time to response and remission were significantly shorter with measurement-based care (for response, 5.6 weeks compared with 11.6 weeks, and for remission, 10.2 weeks comparedwith 19.2weeks).HAM-Dscores decreasedsignificantly in both groups, but the reduction was significantly larger for the measurement-based care group (217.8 compared with 213.6). The measurement-based care group had significantlymoretreatment adjustments (44comparedwith 23) and higher antidepressant dosages from week 2 to week 24. Rates of study discontinuation, adverse effects, and concomitant medications did not differ between groups. Conclusions: The results demonstrate the feasibility and effectiveness of measurement-based care for outpatients with moderate to severe major depression, suggesting that this approach can be incorporated in the clinical care of patients with major depression.

URLView the original
Indexed BySCIE
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000362151100014
The Source to ArticleScopus
Fulltext Access
Citation statistics
Cited Times [WOS]:120   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorXiang Y.-T.; Wang G.
AffiliationFrom the Mood Disorders Center and Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing; the Center of Depression, Beijing Institute for Brain Disorders and China Clinical Research Center for Mental Disor
Recommended Citation
GB/T 7714
Guo T.,Xiang Y.-T.,Xiao L.,et al. Measurement-based care versus standard care for major depression: A randomized controlled trial with blind raters[J]. American Journal of Psychiatry,2015,172(10):1004.
APA Guo T.,Xiang Y.-T.,Xiao L.,Hu C.-Q.,Chiu H.F.K.,Ungvari G.S.,Correll C.U.,Lai K.Y.C.,Feng L.,Geng Y.,Feng Y.,&Wang G..(2015).Measurement-based care versus standard care for major depression: A randomized controlled trial with blind raters.American Journal of Psychiatry,172(10),1004.
MLA Guo T.,et al."Measurement-based care versus standard care for major depression: A randomized controlled trial with blind raters".American Journal of Psychiatry 172.10(2015):1004.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Guo T.]'s Articles
[Xiang Y.-T.]'s Articles
[Xiao L.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Guo T.]'s Articles
[Xiang Y.-T.]'s Articles
[Xiao L.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Guo T.]'s Articles
[Xiang Y.-T.]'s Articles
[Xiao L.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.