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Nondestructive and objective assessment of the vestibular function in rodent models: A review
Yang,Xiaojie1; Sun,Peng1,2; Wu,Jian Ping3; Jiang,Weitao1; Vai,Mang I.2; Pun,Sio Hang2; Peng,Cheng1; Chen,Fangyi1
2019
Source PublicationNeuroscience Letters
ISSN0304-3940
AbstractThe normal function of the vestibular system is crucial for the sense of balance. The techniques used to assess the vestibular function plays a vital role in the research of the vestibular system. In this article, we have systematically reviewed some popular methods employing vestibular reflexes and vestibular evoked potentials for assessing the vestibular function in rodent models. These vestibular reflexes and vestibular evoked potentials to effective stimuli have been used as nondestructive and objective functional measures. The main types of vestibular reflexes include the vestibulo-ocular reflex (VOR), vestibulocollic reflex (VCR), and vestibulo-sympathetic reflex (VSR). They are all capable of indicating the functions of the semicircular canals and otoliths. However, the VOR assessment is much more prevalently used because of the relatively stereotypical inputoutput relationship and simple motion pattern of the ocular response. In contrast, the complicated motion pattern and small gain of the VCR response, as well as the undesired component possibly contributed from the acceleration receptors outside the labyrinths in the VSR response, restrict the widespread applications of VCR and VSR in the assessment of the vestibular system. The vestibular evoked myogenic potentials (VEMPs) and vestibular sensory evoked potentials (VsEPs) are the two typical evoked potentials that have been also employed for evaluating the vestibular function. Through exploiting different types of the VEMPs, the saccular and utricular functions can be evaluated separately. The sound-induced VEMPs, moreover, are capable of noninvasively assessing the unilateral vestibular function. The VsEPs, via the morphology of their signal waveforms, enable the access to the location-specific information that indicates the functional statuses of different components within the vestibular neural pathway.
KeywordRodent models Vestibular evoked myogenic potentials (VEMPs) Vestibular function Vestibular sensory evoked potentials (VsEPs) Vestibulo-Ocular reflex (VOR) Vestibulo-Sympathetic reflex (VSR) Vestibulocollic reflex (VCR)
DOI10.1016/j.neulet.2019.134608
URLView the original
Language英语
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Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorChen,Fangyi
Affiliation1.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China
2.State Key Laboratory of Analog and Mixed-Signal VLSI,University of Macau,Macau,China
3.Academy of Advanced Interdisciplinary Studies,Southern University of Science and Technology,Shenzhen,518055,China
Recommended Citation
GB/T 7714
Yang,Xiaojie,Sun,Peng,Wu,Jian Ping,et al. Nondestructive and objective assessment of the vestibular function in rodent models: A review[J]. Neuroscience Letters,2019.
APA Yang,Xiaojie,Sun,Peng,Wu,Jian Ping,Jiang,Weitao,Vai,Mang I.,Pun,Sio Hang,Peng,Cheng,&Chen,Fangyi.(2019).Nondestructive and objective assessment of the vestibular function in rodent models: A review.Neuroscience Letters.
MLA Yang,Xiaojie,et al."Nondestructive and objective assessment of the vestibular function in rodent models: A review".Neuroscience Letters (2019).
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