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The feasibility of low-dose CT protocols for coronary artery calcium scoring and PET attenuation correction in cardiac PET/CT
Wu,Tung Hsin1; Lu,Kun Mu2; Wu,Nien Yun1,3; Wang,Shyh Jen3; Mok,Greta S.P.5; Yang,Bang Hung1,3; Yang,Ching Ching4
2015-03-06
Source PublicationNuclear Medicine Communications
ISSN0143-3636
Volume36Issue:4Pages:376-385
AbstractIntroduction The purpose of this study was to investigate the feasibility of using low-dose computed tomography (CT) in coronary artery calcium scoring and PET attenuation correction for patients in different weight categories undergoing cardiac PET/CT examinations. Materials and methods Calcium scoring computed tomography (CSCT) scans and PET scans of anthropomorphic cardiac phantoms simulating normalweight, mildly obese, and severely obese patients were acquired with a hybrid PET/CT scanner. CSCT images were acquired at 120 kVp, with tube current ranging from 10 to 550 mA. PET scans were performed in three-dimensional mode, with acquisition time of 3 min/bed position. The image quality of cardiac PET/CT was evaluated by assessing the signal-to-noise ratio. CT-based coronary artery calcium quantification was performed using the Agatston scoring system. Results On the basis of our results, the CSCT protocols using tube currents of 50 and 150mA should be able to achieve the lowest possible radiation dose while maintaining the desired image quality for normal-weight and mildly obese patients undergoing cardiac PET/CT examinations, respectively. When the proposed low-dose CSCT protocols were performed, radiation dose could be reduced by 83.34 and 50% compared with those from CSCT scans acquired with standard tube current settings for normal-weight and mildly obese patients, respectively. In the scanning of severely obese patients, an increase in tube voltage or current would help improve the reliability of image information provided by cardiac PET/CT. Conclusion Our study demonstrated the feasibility of lowdose CT protocols for coronary artery calcium scoring and PET attenuation correction in cardiac PET/CT to examine patients in different weight categories. The calculations performed in this work should be able to provide practical information to achieve necessary diagnostic information while keeping radiation dose as low as reasonably achievable.
KeywordAgatston score attenuation correction cardiac PET/CT radiation dose
DOI10.1097/MNM.0000000000000251
URLView the original
Language英语
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Department of Biomedical Imaging and Radiological Sciences,National Yang Ming University,Taipei,Taiwan
2.Department of Radiology,Shin Kong Wu Ho-Su Memorial Hospital,Taipei,Taiwan
3.Department of Nuclear Medicine,Taipei Veterans General Hospital,Taipei,Taiwan
4.Department of Medical Imaging and Radiological Sciences,Tzu-Chi College of Technology,Hualien,880, Sec. 2, Chien-Kuo Rd.,970,Taiwan
5.Biomedical Imaging Laboratory,Department of Electrical and Computer Engineering,University of Macau,Macau,Macao
Recommended Citation
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Wu,Tung Hsin,Lu,Kun Mu,Wu,Nien Yun,et al. The feasibility of low-dose CT protocols for coronary artery calcium scoring and PET attenuation correction in cardiac PET/CT[J]. Nuclear Medicine Communications,2015,36(4):376-385.
APA Wu,Tung Hsin.,Lu,Kun Mu.,Wu,Nien Yun.,Wang,Shyh Jen.,Mok,Greta S.P..,...&Yang,Ching Ching.(2015).The feasibility of low-dose CT protocols for coronary artery calcium scoring and PET attenuation correction in cardiac PET/CT.Nuclear Medicine Communications,36(4),376-385.
MLA Wu,Tung Hsin,et al."The feasibility of low-dose CT protocols for coronary artery calcium scoring and PET attenuation correction in cardiac PET/CT".Nuclear Medicine Communications 36.4(2015):376-385.
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