UM
Advanced sensitivity amplification strategies for voltammetric immunosensors of tumor marker: State of the art
Zheng,Yun1; Li,Jianding1,2; Zhou,Bingpu1; Ian,Hou1; Shao,Huaiyu1
2021-04-15
Source PublicationBiosensors and Bioelectronics
ISSN0956-5663
Volume178
AbstractImmunosensors are molecular recognition-based solid-state biosensing devices, in which the immunochemical reactions are coupled with transducers. As biologic or biochemical substances produced by tumor cells, tumor marker plays an important role in clinical diagnosis and treatment of cancer because its concentration is related to tumor size, clinical stage, and predicting prognosis. Voltammetric immunosensors based on the electrochemical analysis technique provide a sensitive electroanalytical approach for quantitatively detecting tumor markers by measuring the current as a function of the potential. To satisfy the need for accurate monitoring of tumor markers in low-concentration and their slight changes in concentration, the primary aim of developing a novel voltammetric immunosensor is to improve its sensitivity and limit of detection. Compared with traditional immunoassay, the advanced sensitivity-amplified immunosensors have applied appropriate amplification strategies to convert the bio-signal of antigen-antibody recognition events to the high electrochemical signal of redox species. Building on the significant concepts, sensitivity and limit of detection, we describe how the performance of voltammetric immunosensors can be improved by various sensitivity amplification mechanisms: (1) construction of labels with a high loading of signal species; (2) introduction of interfacial reaction initiated by functionalized nanomaterials; (3) building a synergistic connection between labels and substrate. The review ends with a summary of the shortage of current sensitivity amplified immunosensors and the perspective of enhancement strategies for more simple, efficient, and reliable voltammetric immunosensors.
KeywordAmplification strategies Cascade reaction Mesoporous silica Signal species Tumor markers Voltammetric immunosensors
DOI10.1016/j.bios.2021.113021
URLView the original
Language英语
Fulltext Access
Citation statistics
Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorZhou,Bingpu
Affiliation1.Joint Key Laboratory of the Ministry of Education,Institute of Applied Physics and Materials Engineering,University of Macau,Taipa,999078,China
2.School of Science,Huzhou University,Huzhou,313000,China
First Author AffilicationINSTITUTE OF APPLIED PHYSICS AND MATERIALS ENGINEERING
Corresponding Author AffilicationINSTITUTE OF APPLIED PHYSICS AND MATERIALS ENGINEERING
Recommended Citation
GB/T 7714
Zheng,Yun,Li,Jianding,Zhou,Bingpu,et al. Advanced sensitivity amplification strategies for voltammetric immunosensors of tumor marker: State of the art[J]. Biosensors and Bioelectronics,2021,178.
APA Zheng,Yun,Li,Jianding,Zhou,Bingpu,Ian,Hou,&Shao,Huaiyu.(2021).Advanced sensitivity amplification strategies for voltammetric immunosensors of tumor marker: State of the art.Biosensors and Bioelectronics,178.
MLA Zheng,Yun,et al."Advanced sensitivity amplification strategies for voltammetric immunosensors of tumor marker: State of the art".Biosensors and Bioelectronics 178(2021).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zheng,Yun]'s Articles
[Li,Jianding]'s Articles
[Zhou,Bingpu]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zheng,Yun]'s Articles
[Li,Jianding]'s Articles
[Zhou,Bingpu]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zheng,Yun]'s Articles
[Li,Jianding]'s Articles
[Zhou,Bingpu]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.