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Near-Infrared Chemiluminescent Carbon Nanodots and Their Application in Reactive Oxygen Species Bioimaging
Cheng-Long Shen1; Qing Lou1; Jin-Hao Zang1; Kai-Kai Liu1; Song-Nan Qu2; Lin Dong1; Chong-Xin Shan1
2020-04-01
Source PublicationAdvanced Science
ISSN2198-3844
Volume7Issue:8
Abstract

Reactive oxygen species (ROS) are generated in the body and related to many pathophysiological processes. Hence, detection of ROS is indispensable in understanding, diagnosis, and treatment of many diseases. Here, near-infrared (NIR) chemiluminescent (CL) carbon nanodots (CDs) are fabricated for the first time and their CL quantum yield can reach 9.98 × 10 einstein mol, which is the highest value ever reported for CDs until now. Nanointegration of NIR CDs and peroxalate (P-CDs) through the bridging effect of amphiphilic triblock copolymer can serve as turn-on probes for the detection and imaging of hydrogen peroxide (HO). Considering high efficiency and large penetration depth of NIR photons, the P-CDs are employed in bioimaging HO in vitro and in vivo, and the detection limit can reach 5 × 10 m, among the best reported of CDs-based sensors. Moreover, imaging of inflammatory HO in a mouse model of peritonitis is achieved by employing the P-CDs as sensors. The results may provide a clue for the diagnosis and treatment of inflammation or cancers employing CL CDs as sensors.

KeywordBioimaging Carbon Nanodots Chemiluminescence Reactive Oxygen Species Sensors Turn-on Probes
DOI10.1002/advs.201903525
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000529216500022
Scopus ID2-s2.0-85081273113
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Cited Times [WOS]:50   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionINSTITUTE OF APPLIED PHYSICS AND MATERIALS ENGINEERING
Corresponding AuthorQing Lou
Affiliation1.Henan Key Laboratory of Diamond Optoelectronic Materials and Devices,Key Laboratory of Materials Physics,Ministry of Education,School of Physics and Microelectronics,Zhengzhou University,Zhengzhou,450052,China
2.Joint Key Laboratory of the Ministry of Education,Institute of Applied Physics and Materials Engineering,University of Macau,999078,Macao
Recommended Citation
GB/T 7714
Cheng-Long Shen,Qing Lou,Jin-Hao Zang,et al. Near-Infrared Chemiluminescent Carbon Nanodots and Their Application in Reactive Oxygen Species Bioimaging[J]. Advanced Science,2020,7(8).
APA Cheng-Long Shen,Qing Lou,Jin-Hao Zang,Kai-Kai Liu,Song-Nan Qu,Lin Dong,&Chong-Xin Shan.(2020).Near-Infrared Chemiluminescent Carbon Nanodots and Their Application in Reactive Oxygen Species Bioimaging.Advanced Science,7(8).
MLA Cheng-Long Shen,et al."Near-Infrared Chemiluminescent Carbon Nanodots and Their Application in Reactive Oxygen Species Bioimaging".Advanced Science 7.8(2020).
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