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Microfluidic immobilized enzyme reactors for continuous biocatalysis
Zhu,Yujiao1,2,3; Chen,Qingming1,2; Shao,Liyang4; Jia,Yanwei3,5,6; Zhang,Xuming1,2
Source PublicationReaction Chemistry and Engineering

Biocatalysis has attracted significant attention owing to its environmental-friendly nature, high efficiency, and remarkable selectivity for reactions. However, enzymes, which are powerful catalysts used in biocatalysis, suffer from low stability when used for long-term operations in solution and a gradual decrease in activity during storage. Microfluidic reactors are devices known for their smaller dimensions, large surface-to-volume ratios, and well-defined reaction times. Enzymes immobilized in such microfluidic reactors can exhibit distinct benefits, such as fast reaction rate, high storage stability, suppressed autolysis, and ease of use. The use of microfluidic immobilized enzyme reactors (μ-IMERs) offers several advantages over traditional technologies in performing biocatalytic reactions, such as low energy consumption, rapid heat exchange, fast mass transfer, high efficiency, and superior repeatability. In this review, the strategies of employing μ-IMERs for continuous biocatalysis have been investigated via a top-down approach. First, from the macroscopic perspective, the fabrication techniques of microfluidic reactors are presented encompassing materials, configurations, and technologies. Then, from the microscopic point of view, several strategies are discussed for the internal structural designs of microfluidic reactors. Moreover, when we move to the nanoscopic level, attention is paid to the choice of enzyme immobilization techniques for performance enhancement. Finally, the scalability of microfluidics that transfers biocatalysis from laboratory to industrial production was investigated. This review is intended to provide a guideline for using biocatalysis in microreactors and expediting the progress of this important research area.

URLView the original
Indexed BySCIE
WOS Research AreaChemistry ; Engineering
WOS SubjectChemistry, Multidisciplinary ; Engineering, Chemical
WOS IDWOS:000507993700014
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Cited Times [WOS]:20   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorZhang,Xuming
Affiliation1.Department of Applied Physics,Hong Kong Polytechnic University,Hong Kong,Hong Kong
2.Hong Kong Polytechnic University,Shenzhen Research Institute,Shenzhen,China
3.State Key Laboratory of Analog and Mixed Signal VLSI,Institute of Microelectronics,University of Macau,Macao
4.Department of Electrical and Electronic Engineering,Southern University of Science and Technology,Shenzhen,China
5.Faculty of Science and Technology,University of Macau,Macao
6.Faculty of Health Sciences,University of Macau,Macao
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Zhu,Yujiao,Chen,Qingming,Shao,Liyang,et al. Microfluidic immobilized enzyme reactors for continuous biocatalysis[J]. Reaction Chemistry and Engineering,2020,5(1):9-32.
APA Zhu,Yujiao,Chen,Qingming,Shao,Liyang,Jia,Yanwei,&Zhang,Xuming.(2020).Microfluidic immobilized enzyme reactors for continuous biocatalysis.Reaction Chemistry and Engineering,5(1),9-32.
MLA Zhu,Yujiao,et al."Microfluidic immobilized enzyme reactors for continuous biocatalysis".Reaction Chemistry and Engineering 5.1(2020):9-32.
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