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Turning on/off satellite droplet ejection for flexible sample delivery on digital microfluidics
Li,Haoran1,2; Shen,Ren1,2; Dong,Cheng1; Chen,Tianlan1; Jia,Yanwei1,2,3; Mak,Pui In1,2; Martins,Rui P.1,2,4
2020-10-21
Source PublicationLab on a Chip
ISSN1473-0197
Volume20Issue:20Pages:3709-3719
Abstract

Digital microfluidics has the potential to minimize and automate reactions in biochemical labs. However, the complexity of drop manipulation and sample preparation on-chip has limited its incorporation into daily workflow. In this paper, we report a novel method for flexible sample delivery on digital microfluidics in a wide volume range spanning four orders of magnitude from picoliters to nanoliters. The method is based on the phenomenon of satellite droplet ejection, triggered by a sudden change in the strength of the electric field across a drop on a hydrophobic dielectric surface. By precisely modulating the actuation signal with convenient external electric controls, satellite droplet ejection can be turned on to dispense samples or turned off to transport picking-up drops. A pico-dosing design is presented and validated in this work to demonstrate the direct and flexible on-chip sample delivery. This approach could pave the way for the acceptance of microfluidics as a common platform for daily reactions to realize lab-on-a-chip.

DOI10.1039/d0lc00701c
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Science & Technology - Other Topics ; Instruments & Instrumentation
WOS SubjectBiochemical Research Methods ; Chemistry, Multidisciplinary ; Chemistry, Analytical ; Nanoscience & Nanotechnology ; Instruments & Instrumentation
WOS IDWOS:000577744000014
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Document TypeJournal article
CollectionINSTITUTE OF MICROELECTRONICS
Corresponding AuthorJia,Yanwei
Affiliation1.State Key Laboratory of Analog and Mixed-Signal Vlsi,Institute of Microelectronics,University of Macau,Macao
2.Faculty of Science and Technology-ECE,University of Macau,Macao
3.Faculty of Health Sciences,University of Macau,Macao
4.On Leave from Instituto Superior Técnico,Unversidade de Lisboa,Portugal
First Author AffilicationUniversity of Macau;  Faculty of Science and Technology
Corresponding Author AffilicationUniversity of Macau;  Faculty of Science and Technology;  Faculty of Health Sciences
Recommended Citation
GB/T 7714
Li,Haoran,Shen,Ren,Dong,Cheng,et al. Turning on/off satellite droplet ejection for flexible sample delivery on digital microfluidics[J]. Lab on a Chip,2020,20(20):3709-3719.
APA Li,Haoran,Shen,Ren,Dong,Cheng,Chen,Tianlan,Jia,Yanwei,Mak,Pui In,&Martins,Rui P..(2020).Turning on/off satellite droplet ejection for flexible sample delivery on digital microfluidics.Lab on a Chip,20(20),3709-3719.
MLA Li,Haoran,et al."Turning on/off satellite droplet ejection for flexible sample delivery on digital microfluidics".Lab on a Chip 20.20(2020):3709-3719.
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