Recent advances in nanomaterial-based synergistic combination cancer immunotherapy
Sang,Wei1,2; Zhang,Zhan1,2; Dai,Yunlu1,2; Chen,Xiaoyuan3
Source PublicationChemical Society Reviews
AbstractIn recent years, conventional treatments including surgery, chemotherapy and radiotherapy have been the main approaches in tumour therapy. Cancer immunotherapy is a new therapeutic modality to fight cancer by harnessing the power of patients' own immune system. Ongoing research related to these therapies has demonstrated their advantages and intrinsic limitations. Nanomaterial-based platforms are utilized in these emerging fields. In particular, a combination of other treatment methods with cancer immunotherapy to achieve precision medicine and prevent recurrence and metastasis, could improve patients' outcome. The combined multiple treatments have superior efficacy to any monotherapy alone in producing improved anti-cancer activity. Therefore, it's necessary to summarise research advances in nanomaterial-based combination cancer immunotherapy contributing to clinical transformation. This review is based on the principles of cancer immunotherapy and the combined treatment design reflected by advances in materials science, including the structures of nanoplatforms and their underlying mechanisms towards cancer. The ultimate goals are to stimulate the design of better strategies for versatile use in the future based on biomaterial engineering methods to enhance the efficacy of combined cancer treatments, and to provide new ideas for the prospects of a synergistic cancer combination immunotherapy for clinical application transformation.
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Scopus ID2-s2.0-85068997035
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Cited Times [WOS]:102   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorDai,Yunlu
Affiliation1.Cancer Centre,Faculty of Health Sciences,University of Macau,999078,Macao
2.Institute of Translational Medicine,Faculty of Health Sciences,University of Macau,999078,Macao
3.Laboratory of Molecular Imaging and Nanomedicine,National Institute of Biomedical Imaging and Bioengineering,National Institutes of Health,Bethesda,20892,United States
First Author AffilicationCancer Centre;  Faculty of Health Sciences
Corresponding Author AffilicationCancer Centre;  Faculty of Health Sciences
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GB/T 7714
Sang,Wei,Zhang,Zhan,Dai,Yunlu,et al. Recent advances in nanomaterial-based synergistic combination cancer immunotherapy[J]. Chemical Society Reviews,2019,48(14):3771-3810.
APA Sang,Wei,Zhang,Zhan,Dai,Yunlu,&Chen,Xiaoyuan.(2019).Recent advances in nanomaterial-based synergistic combination cancer immunotherapy.Chemical Society Reviews,48(14),3771-3810.
MLA Sang,Wei,et al."Recent advances in nanomaterial-based synergistic combination cancer immunotherapy".Chemical Society Reviews 48.14(2019):3771-3810.
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