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Efficient Polysulfide-Based Nanotheranostics for Triple-Negative Breast Cancer: Ratiometric Photoacoustics Monitored Tumor Microenvironment-Initiated H2S Therapy
Li,Jie1,2; Li,Xiang2; Yuan,Yan1; Wang,Qi2; Xie,Lisi3; Dai,Yunlu3; Wang,Wenjun4; Li,Lin1; Lu,Xiaomei1; Fan,Quli2; Huang,Wei1
2020-10-01
Source PublicationSmall
ISSN1613-6810
Volume16Issue:39
AbstractThe incidence of triple-negative breast cancer (TNBC) is difficult to predict, and TNBC has a high mortality rate among women worldwide. In this study, a theranostics approach is developed for TNBC with ratiometric photoacoustic monitored thiol-initiated hydrogen sulfide (HS) therapy. The ratiometric photoacoustic (PA) probe (CY) with a thiol-initiated HS donor (PSD) to form a nanosystem (CY-PSD nanoparticles) is integrated. In this theranostics approach, HS generated from PSD is sensed by CY based on ratiometric PA signals, which simultaneously pinpoints the tumor region. Additionally, HS is cytotoxic toward TNBC cells (MDA-MB 231), showing a tumor inhibition rate of 63%. To further verify its pharmacological mechanism, proteomics analysis is performed on tumors treated with CY-PSD nanoparticles. Cells are killed by the significant mitochondrial dysfunction via supressed energy supply and apoptosis initiation. Besides, the observed inhibition of oxidative stress also generates the cytotoxicity. Significant Kyoto Encyclopedia of Genes Genomes pathways related to TNBC are found to be inhibited. This HS theranostics approach updates the current anticancer therapies which brings promise for women suffering malignant breast cancer.
Keywordhydrogen sulfide polysulfide ratiometric photoacoustics theranostics triple-negative breast cancer
DOI10.1002/smll.202002939
URLView the original
Language英语
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorLi,Lin
Affiliation1.Jiangsu-Singapore Joint Research Center for Organic/Bio-Electronics & Information Displays and Institute of Advanced Materials (IAM),Nanjing Tech University,Nanjing,211816,China
2.Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM),Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM),Nanjing University of Posts & Telecommunications,Nanjing,210023,China
3.Cancer Centre and Institute of Translational Medicine,Faculty of Health Sciences,University of Macau,999078,Macao
4.Key Lab of Optical Communication Science and Technology of Shandong Province & School of Physics Science and Information Engineering,Liaocheng University,Liaocheng,252059,China
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GB/T 7714
Li,Jie,Li,Xiang,Yuan,Yan,et al. Efficient Polysulfide-Based Nanotheranostics for Triple-Negative Breast Cancer: Ratiometric Photoacoustics Monitored Tumor Microenvironment-Initiated H2S Therapy[J]. Small,2020,16(39).
APA Li,Jie,Li,Xiang,Yuan,Yan,Wang,Qi,Xie,Lisi,Dai,Yunlu,Wang,Wenjun,Li,Lin,Lu,Xiaomei,Fan,Quli,&Huang,Wei.(2020).Efficient Polysulfide-Based Nanotheranostics for Triple-Negative Breast Cancer: Ratiometric Photoacoustics Monitored Tumor Microenvironment-Initiated H2S Therapy.Small,16(39).
MLA Li,Jie,et al."Efficient Polysulfide-Based Nanotheranostics for Triple-Negative Breast Cancer: Ratiometric Photoacoustics Monitored Tumor Microenvironment-Initiated H2S Therapy".Small 16.39(2020).
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