UM
Exploration the effect of structural adjustment on identifying medium and bio-targeting based on two similar coumarin compounds
Yao,Shun1; Zhang,Gaojian2; Wang,Haiyan1; Song,Jinjin3; Liu,Tianyan3; Yang,Mingdi1,5; Yu,Jianhua1; Yang,Xingyuan2; Tian,Yupeng1; Zhang,Xuanjun4; Zhou,Hongping1
2018-11-01
Source PublicationSensors and Actuators, B: Chemical
ISSN0925-4005
Volume272Pages:574-581
AbstractTwo novel similar structural coumarin-based fluorescent compounds L1 and L2 employing ether oxygen chain and 2 – pyridine unit had been prepared to explore the effect of structural adjustment on property. The prepared L2 through slightly adjusting structure of L1 exhibited the prominent fluorescence responses to Hg and Cu in HO, which could monitor the corresponding metals ion in mitochondria of Hela cells, but L1 only recognized Hg through turn-on fluorescence response in CHOH/HO, fluorescence co-localization studies illustrated that the L1 mainly located at lysosome. The recognition mechanism had been established by H NMR titration, Job's plot, MAlDI-TOF mass spectrometry and single crystal structure. Bio-imaging experiments revealed that L1 and L2 could qualitatively monitor Hg or Cu in Hela cells and mouse kidney tissues.
KeywordBio-imaging application Copper ion Fluorescence probes Lysosome Mercuric ion Mitochondria
DOI10.1016/j.snb.2018.05.143
URLView the original
Language英语
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorZhou,Hongping
Affiliation1.College of Chemistry and Chemical Engineering,Anhui University and Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province,AnHui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials,Hefei,230601,China
2.Institute of Physical Science and Information Technology,Faculty of Health Sciences,Anhui University,Hefei,230601,China
3.School of Life Sciences,Anhui University,Hefei,230601,China
4.Faculty of Health Sciences,University of Macau,Taipa,Macao
5.School of Materials and Chemical Engineering,Anhui Jianzhu University,Hefei,230601,China
Recommended Citation
GB/T 7714
Yao,Shun,Zhang,Gaojian,Wang,Haiyan,et al. Exploration the effect of structural adjustment on identifying medium and bio-targeting based on two similar coumarin compounds[J]. Sensors and Actuators, B: Chemical,2018,272:574-581.
APA Yao,Shun,Zhang,Gaojian,Wang,Haiyan,Song,Jinjin,Liu,Tianyan,Yang,Mingdi,Yu,Jianhua,Yang,Xingyuan,Tian,Yupeng,Zhang,Xuanjun,&Zhou,Hongping.(2018).Exploration the effect of structural adjustment on identifying medium and bio-targeting based on two similar coumarin compounds.Sensors and Actuators, B: Chemical,272,574-581.
MLA Yao,Shun,et al."Exploration the effect of structural adjustment on identifying medium and bio-targeting based on two similar coumarin compounds".Sensors and Actuators, B: Chemical 272(2018):574-581.
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