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Ratiometric polymer probe for detection of peroxynitrite and the application for live-cell imaging
Lao,Hio Kuan; Tan,Jingyun; Wang,Chunfei; Zhang,Xuanjun
2019-09-24
Source PublicationMolecules
ISSN1420-3049
Volume24Issue:19
Abstract

Peroxynitrite (ONOO) is one of the sources of oxidation stress involved in many biological signaling pathways. The role of ONOO being a double-edged sword in biological systems drives the development of effective detection tools. In this work, a boronate-based polymeric fluorescent probe PB-PVA was synthesized and the probe performance was evaluated. The probe exhibits ratiometric sensing of ONOO in a range of 0–6 µM. There is good linear relationship between the probe fluorescence intensity ratio and ONOO concentration. The probe also displays moderate selectivity towards ONOO over other ROS. Moreover, it is water-soluble and possesses good biocompatibility which aids the imaging of ONOO in living cells. These properties could make the probe a promising tool in in vitro study related to ONOO

KeywordCell Imaging Fluorescent Probe Peroxynitrite Polymer Probe Ratiometric
DOI10.3390/molecules24193465
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000496242300050
Scopus ID2-s2.0-85072636572
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Document TypeJournal article
CollectionCentre of Reproduction, Development and Aging
Faculty of Health Sciences
Cancer Centre
Corresponding AuthorZhang,Xuanjun
AffiliationCancer Centre and Centre of Reproduction,Development and Aging,Faculty of Health Sciences,University of Macau,999078,Macao
First Author AffilicationCancer Centre
Corresponding Author AffilicationCancer Centre
Recommended Citation
GB/T 7714
Lao,Hio Kuan,Tan,Jingyun,Wang,Chunfei,et al. Ratiometric polymer probe for detection of peroxynitrite and the application for live-cell imaging[J]. Molecules,2019,24(19).
APA Lao,Hio Kuan,Tan,Jingyun,Wang,Chunfei,&Zhang,Xuanjun.(2019).Ratiometric polymer probe for detection of peroxynitrite and the application for live-cell imaging.Molecules,24(19).
MLA Lao,Hio Kuan,et al."Ratiometric polymer probe for detection of peroxynitrite and the application for live-cell imaging".Molecules 24.19(2019).
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