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Semiconducting Polymer Dots with Dual-Enhanced NIR-IIa Fluorescence for Through-Skull Mouse-Brain Imaging
Zhang,Zhe1,2; Fang,Xiaofeng1; Liu,Zhihe1; Liu,Haichao2; Chen,Dandan1; He,Shuqing1; Zheng,Jie2; Yang,Bing2; Qin,Weiping2; Zhang,Xuanjun3; Wu,Changfeng1
2020-02-24
Source PublicationAngewandte Chemie - International Edition
ISSN1433-7851
Volume59Issue:9Pages:3691-3698
Abstract

Fluorescence probes in the NIR-IIa region show drastically improved imaging owing to the reduced photon scattering and autofluorescence in biological tissues. Now, NIR-IIa polymer dots (Pdots) are developed with a dual fluorescence enhancement mechanism. First, the aggregation induced emission of phenothiazine was used to reduce the nonradiative decay pathways of the polymers in condensed states. Second, fluorescence quenching was minimized by different levels of steric hindrance to further boost the fluorescence. The resulting Pdots displayed a fluorescence QY of ca. 1.7 % in aqueous solution, suggesting an enhancement of ca. 21 times in comparison with the original polymer in tetrahydrofuran (THF) solution. Small-animal imaging by using the NIR-IIa Pdots exhibited a remarkable improvement in penetration depth and signal to background ratio, as confirmed by through-skull and through-scalp fluorescent imaging of the cerebral vasculature of live mice.

KeywordAggregation-induced Emission Molecular Engineering Nir-ii Fluorescence Imaging Polymer Dots Semiconducting Polymers
DOI10.1002/anie.201914397
URLView the original
Indexed BySCIE ; IC
Language英語English
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000508312000001
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Cited Times [WOS]:36   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorWu,Changfeng
Affiliation1.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China
2.State Key Laboratory of Integrated Optoelectronics,College of Electronic Science and Engineering,Jilin University,Changchun,Jilin,130012,China
3.Cancer Centre and Centre of Reproduction,Development and Aging,Faculty of Health Science,University of Macau,Taipa,999078,Macao
Recommended Citation
GB/T 7714
Zhang,Zhe,Fang,Xiaofeng,Liu,Zhihe,et al. Semiconducting Polymer Dots with Dual-Enhanced NIR-IIa Fluorescence for Through-Skull Mouse-Brain Imaging[J]. Angewandte Chemie - International Edition,2020,59(9):3691-3698.
APA Zhang,Zhe.,Fang,Xiaofeng.,Liu,Zhihe.,Liu,Haichao.,Chen,Dandan.,...&Wu,Changfeng.(2020).Semiconducting Polymer Dots with Dual-Enhanced NIR-IIa Fluorescence for Through-Skull Mouse-Brain Imaging.Angewandte Chemie - International Edition,59(9),3691-3698.
MLA Zhang,Zhe,et al."Semiconducting Polymer Dots with Dual-Enhanced NIR-IIa Fluorescence for Through-Skull Mouse-Brain Imaging".Angewandte Chemie - International Edition 59.9(2020):3691-3698.
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