UM  > Faculty of Health Sciences
Protein-modified CuS nanotriangles for dual-modal photoacoustic and magnetic resonance imaging
Yuan,Zhen; Gao,Duyang
2020
Conference NameSymposium on Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications, held at SPIE BiOS Conference
Source PublicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11254
Conference DateFEB 02-03, 2020
Conference PlaceSan Francisco, CA
Abstract

Controllable preparation of water-soluble multifunctional nanoprobes is of great significance for cancer early diagnosis. In this study, protein-modified hydrophilic copper sufide (CuS) nanotriangles with tunable absorption in the second near-infrared region are developed in the presence of halide ions. Further, DTPA-Gd3+ is conjugated on it by using the unique characteristics of the protein-protected nanotriangles. Specifically, the asobtained nanostructures are investigated as contrast agents for enhanced in vivo photoacoustic/magnetic resonance dual-modal tumor imaging. More importantly, in vitro and in vivo toxicity analysis are also performed, which show that the dual -modal nanoprobes are biocompatible for most of the cases. It is demonstrated that the novel asprepared protein-modified nanotriangles are able to work as a nanoplatform to construct dual-modal nanoprobes, which paves a new anenue for improving the photoacoustic/magnetic resonance imaging contrast in cancer detection. It should be pointed out that other functional blocks may also be linked on it, which makes it a general method to design multifunctional nanoprobes.

KeywordCus Nanotriangle Dual-modal Nanoprobe Magnetic Resonance Imaging Photoacoustic Imaging Protein-modified
DOI10.1117/12.2542233
URLView the original
Indexed ByCPCI-S
Language英語English
WOS Research AreaEngineering ; Science & Technology - Other Topics ; Optics
WOS SubjectEngineering, Biomedical ; Nanoscience & Nanotechnology ; Optics
WOS IDWOS:000546254100008
Fulltext Access
Citation statistics
Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document TypeConference paper
CollectionFaculty of Health Sciences
AffiliationFaculty of Health Sciences,University of Macau,Macao
First Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Yuan,Zhen,Gao,Duyang. Protein-modified CuS nanotriangles for dual-modal photoacoustic and magnetic resonance imaging[C],2020.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yuan,Zhen]'s Articles
[Gao,Duyang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yuan,Zhen]'s Articles
[Gao,Duyang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yuan,Zhen]'s Articles
[Gao,Duyang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.