UM
ROS-Responsive Berberine Polymeric Micelles Effectively Suppressed the Inflammation of Rheumatoid Arthritis by Targeting Mitochondria
Fan,Xing xing1; Xu,Meng ze2; Leung,Elaine Lai Han1; Jun,Cai1; Yuan,Zhen2; Liu,Liang1
2020-03-01
Source PublicationNano-Micro Letters
ISSN2311-6706
Volume12Issue:1
Abstract

Rheumatoid arthritis (RA) is an autoimmune disease, which attacks human joint system and causes lifelong inflammatory condition. To date, no cure is available for RA and even the ratio of achieving remission is very low. Hence, to enhance the efficacy of RA treatment, it is essential to develop novel approaches specifically targeting pathological tissues. In this study, we discovered that RA synovial fibroblasts exhibited higher reactive oxygen species (ROS) and mitochondrial superoxide level, which were adopted to develop ROS-responsive nano-medicines in inflammatory microenvironment for enhanced RA treatment. A selenocystamine-based polymer was synthesized as a ROS-responsive carrier nanoplatform, and berberine serves as a tool drug. By assembling, ROS-responsive berberine polymeric micelles were fabricated, which remarkably increased the uptake of berberine in RA fibroblast and improved in vitro and in vivo efficacy ten times higher. Mechanistically, the anti-RA effect of micelles was blocked by the co-treatment of AMPK inhibitor or palmitic acid, indicating that the mechanism of micelles was carried out through targeting mitochondrial, suppressing lipogenesis and finally inhibiting cellular proliferation. Taken together, our ROS-responsive nano-medicines represent an effective way of preferentially releasing prodrug at the inflammatory microenvironment and improving RA therapeutic efficacy.

KeywordBerberine Nanoparticles Oxygen Consumption Rate Reactive Oxygen Species Rheumatoid Arthritis
DOI10.1007/s40820-020-0410-x
URLView the original
Indexed BySCIE
WOS Research AreaScience & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS IDWOS:000522033200001
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorYuan,Zhen; Liu,Liang
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine,Macau Institute For Applied Research in Medicine and Health,Macau University of Science and Technology,Taipa,Avenida Wai Long,Macao
2.Faculty of Health Sciences,University of Macau,Taipa,Macao
First Author AffilicationUniversity of Macau
Corresponding Author AffilicationFaculty of Health Sciences;  University of Macau
Recommended Citation
GB/T 7714
Fan,Xing xing,Xu,Meng ze,Leung,Elaine Lai Han,et al. ROS-Responsive Berberine Polymeric Micelles Effectively Suppressed the Inflammation of Rheumatoid Arthritis by Targeting Mitochondria[J]. Nano-Micro Letters,2020,12(1).
APA Fan,Xing xing,Xu,Meng ze,Leung,Elaine Lai Han,Jun,Cai,Yuan,Zhen,&Liu,Liang.(2020).ROS-Responsive Berberine Polymeric Micelles Effectively Suppressed the Inflammation of Rheumatoid Arthritis by Targeting Mitochondria.Nano-Micro Letters,12(1).
MLA Fan,Xing xing,et al."ROS-Responsive Berberine Polymeric Micelles Effectively Suppressed the Inflammation of Rheumatoid Arthritis by Targeting Mitochondria".Nano-Micro Letters 12.1(2020).
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