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Co-encapsulating indocyanine green and CT contrast agent within nanoliposomes for trimodal imaging and near infrared phototherapy of cancer
Xu,Hao1; Ohulchanskyy,Tymish Y.1; Qu,Jinghan3; Yakovliev,Artem1; Ziniuk,Roman1; Yuan,Zhen2; Qu,Junle1
2020-10-01
Source PublicationNanomedicine: Nanotechnology, Biology, and Medicine
ISSN1549-9634
Volume29
Abstract

X-ray CT imaging can be complementary to fluorescence and photoacoustic imaging (FLI and PAI), allowing for high spatial resolution and high-sensitivity multimodal imaging for imaging guided treatment. In this study, the CT contrast agent iohexol was co-encapsulated with indocyanine green (ICG) within nanoliposomes (NLs) to explore their interaction and possible application of this liposomal formulation (LGI) in cancer theranostics. The photophysical properties of LGI were studied to assess the effect of iohexol on ICG that can enhance the efficiency of ICG-based near infrared photodynamic therapy (PDT). The CT, FLI and PA imaging abilities of LGI were also investigated. Furthermore, the near infrared phototherapy of cancer cells in vitro was performed, exhibiting higher phototherapy efficacy of LGI in comparison with other ICG formulations. We conclude that LGI can serve as a highly efficient theranostic nanoplatform for multimodal (fluorescence, CT and PA) imaging and near infrared phototherapy.

KeywordHeavy Atom Effect Liposome Near Infrared Fluorescence Imaging Photoacoustic Imaging Photodynamic Therapy
DOI10.1016/j.nano.2020.102269
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaScience & Technology - Other Topics ; Research & Experimental Medicine
WOS SubjectNanoscience & Nanotechnology ; Medicine, Research & Experimental
WOS IDWOS:000573096700004
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Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorOhulchanskyy,Tymish Y.
Affiliation1.Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province,College of Physics and Optoelectronic Engineering,Shenzhen University,Shenzhen,China
2.Bioimaging Core,Faculty of Health Sciences,University of Macau,Macau,China
3.Faculty of Science Medicine and Health,University of Wollongong,Australia
Recommended Citation
GB/T 7714
Xu,Hao,Ohulchanskyy,Tymish Y.,Qu,Jinghan,et al. Co-encapsulating indocyanine green and CT contrast agent within nanoliposomes for trimodal imaging and near infrared phototherapy of cancer[J]. Nanomedicine: Nanotechnology, Biology, and Medicine,2020,29.
APA Xu,Hao,Ohulchanskyy,Tymish Y.,Qu,Jinghan,Yakovliev,Artem,Ziniuk,Roman,Yuan,Zhen,&Qu,Junle.(2020).Co-encapsulating indocyanine green and CT contrast agent within nanoliposomes for trimodal imaging and near infrared phototherapy of cancer.Nanomedicine: Nanotechnology, Biology, and Medicine,29.
MLA Xu,Hao,et al."Co-encapsulating indocyanine green and CT contrast agent within nanoliposomes for trimodal imaging and near infrared phototherapy of cancer".Nanomedicine: Nanotechnology, Biology, and Medicine 29(2020).
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