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Active-Targeting NIR-II Phototheranostics in Multiple Tumor Models Using Platelet-Camouflaged Nanoprobes
Geng,Xiaorui1,2,3; Gao,Duyang2; Hu,Dehong2; Liu,Quanhong1; Liu,Chengbo2; Yuan,Zhen3; Zhang,Xuanjun3; Liu,Xin2; Sheng,Zonghai2; Wang,Xiaobing1; Zheng,Hairong2
2020-12-16
Source PublicationACS Applied Materials and Interfaces
ISSN1944-8244
Volume12Issue:50Pages:55624-55637
Abstract

Cancer phototheranostics in the second near-infrared window (NIR-II, 1000-1700 nm) has recently attracted much attention owing to its high efficacy and good safety compared with that in the first near-infrared window (NIR-I, 650-950 nm). However, the lack of theranostic nanoagents with active-targeting features limits its further application in cancer precision therapies. Herein, we constructed platelet-camouflaged nanoprobes with active-targeting characteristics for NIR-II cancer phototheranostics. The as-prepared biomimetic nanoprobes can not only escape phagocytosis by macrophages but also specifically bind to CD44 on the surface of most cancer cells. We evaluated the active-targeting performance of biomimetic nanoprobes in pancreatic cancer, breast cancer, and glioma mouse models and achieved NIR-II photoacoustic imaging with a high signal-to-background ratio and photothermal treatment with excellent tumor growth inhibition. Our results show the great potential of platelet-camouflaged nanoprobes with NIR-II active-targeting features for cancer precision diagnosis and efficient therapies.

KeywordActive Targeting Multiple Tumor Models Nir-ii Photoacoustic Imaging Photothermal Therapy Platelet Cell Membrane
DOI10.1021/acsami.0c16872
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000600202300009
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Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorWang,Xiaobing; Zheng,Hairong
Affiliation1.Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry,Ministry of Education,College of Life Sciences,Shaanxi Normal University,Xi'an,710119,China
2.Paul C. Lauterbur Research Center for Biomedical Imaging,Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province,Shenzhen Key Laboratory of Ultrasound Imaging and Therapy,CAS Key Laboratory of Health Informatics,Institute of Biomedical and Health Engineering,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,518055,China
3.Faculty of Health Sciences,University of Macau,Taipa,999078,Macao
First Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Geng,Xiaorui,Gao,Duyang,Hu,Dehong,et al. Active-Targeting NIR-II Phototheranostics in Multiple Tumor Models Using Platelet-Camouflaged Nanoprobes[J]. ACS Applied Materials and Interfaces,2020,12(50):55624-55637.
APA Geng,Xiaorui,Gao,Duyang,Hu,Dehong,Liu,Quanhong,Liu,Chengbo,Yuan,Zhen,Zhang,Xuanjun,Liu,Xin,Sheng,Zonghai,Wang,Xiaobing,&Zheng,Hairong.(2020).Active-Targeting NIR-II Phototheranostics in Multiple Tumor Models Using Platelet-Camouflaged Nanoprobes.ACS Applied Materials and Interfaces,12(50),55624-55637.
MLA Geng,Xiaorui,et al."Active-Targeting NIR-II Phototheranostics in Multiple Tumor Models Using Platelet-Camouflaged Nanoprobes".ACS Applied Materials and Interfaces 12.50(2020):55624-55637.
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