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LncRNA UCA1 maintains the low-tumorigenic and nonmetastatic status by stabilizing E-cadherin in primary prostate cancer cells
Zhao,Xian1; Wang,Yanli1; He,Jianfeng1; Deng,Rong1; Huang,Xiaojun2; Guo,Yanmin1; Li,Lian1; Xie,Ruiyu2; Yu,Jianxiu1,3
2020-10-01
Source PublicationMolecular Carcinogenesis
ISSN0899-1987
Volume59Issue:10Pages:1174-1187
AbstractLong noncoding RNAs (LncRNAs) have emerged as important players in cancer biology. Increasing evidence suggests that LncRNAs are frequently dysregulated in cancer and may function as oncogenes or tumor suppressors. Urothelial carcinoma associated 1 (UCA1), a LncRNA, firstly identified in bladder transitional cell carcinoma, seems to act as an oncogene in many different types of human cancers by promoting cell proliferation and migration. In this study, we revealed a novel biological function of UCA1, which was different from that reported by previous studies, was responsible for maintaining the low-tumorigenic, nonmetastatic phenotypes in primary prostate epithelial cells. UCA1 could stabilize E-cadherin protein by preventing the interaction between E-cadherin and its E3 ligase MDM2, which suppressed MDM2-mediated ubiquitination and degradation of E-cadherin. In addition, we also found that UCA1 acted as a sponge of miR-296-3p, which targeted E-cadherin gene CDH1 messenger RNA at the posttranscription level. Taken together, these findings demonstrated that UCA1 had a new important role in effectively keeping E-cadherin at a high level through a dual mechanism, which maintained primary prostate cancer cells at the low-tumorigenic and nonmetastatic status.
KeywordE-cadherin LncRNA UCA1 MDM2 miR-296-3p primary prostate cancer cells
DOI10.1002/mc.23247
URLView the original
Language英语
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorYu,Jianxiu
Affiliation1.Department of Biochemistry and Molecular Cell Biology,Shanghai Key Laboratory of Tumor Microenvironment and Inflammation,State Key Laboratory of Oncogenes and Related Genes,Shanghai Jiao Tong University School of Medicine,Shanghai,China
2.Faculty of Health of Sciences,Institute of Translational Medicine,University of Macau,Macao
3.Basic Clinical Research Center,School of Medicine,Renji Hospital,Shanghai Jiao Tong University,Shanghai,China
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Zhao,Xian,Wang,Yanli,He,Jianfeng,et al. LncRNA UCA1 maintains the low-tumorigenic and nonmetastatic status by stabilizing E-cadherin in primary prostate cancer cells[J]. Molecular Carcinogenesis,2020,59(10):1174-1187.
APA Zhao,Xian,Wang,Yanli,He,Jianfeng,Deng,Rong,Huang,Xiaojun,Guo,Yanmin,Li,Lian,Xie,Ruiyu,&Yu,Jianxiu.(2020).LncRNA UCA1 maintains the low-tumorigenic and nonmetastatic status by stabilizing E-cadherin in primary prostate cancer cells.Molecular Carcinogenesis,59(10),1174-1187.
MLA Zhao,Xian,et al."LncRNA UCA1 maintains the low-tumorigenic and nonmetastatic status by stabilizing E-cadherin in primary prostate cancer cells".Molecular Carcinogenesis 59.10(2020):1174-1187.
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